Composite tissue allotransplantation - a new era in plastic surgery?

被引：59

作者：

Hettiaratchy, S

Randolph, MA

Petit, F

Lee, WPA

Butler, PEM

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Div Plast Surg,Transplantat Biol Res Ctr, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Plast Surg Res Lab, Boston, MA 02115 USA

[3] CHU Henri Mondor, Dept Plast Reconstruct & Aesthet Surg, Paris, France

[4] Univ Pittsburgh, Sch Med, Div Plast Surg, Pittsburgh, PA USA

[5] Royal Free Hosp, Dept Plast & Reconstruct Surg, London NW3 2QG, England

来源：

BRITISH JOURNAL OF PLASTIC SURGERY | 2004年 / 57卷 / 05期

关键词：

composite tissue transplantation; immunosuppression; tolerance;

D O I：

10.1016/j.bjps.2004.02.012

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Composite tissue allotransplantation (CTA) holds great potential for reconstructive surgery. The recent hand transplants have made this a clinical reality. However, concerns about CTA have divided the medical community. The current transplants require life-long immunosuppression, which could place the recipients at risk of serious complications. In addition despite potent immunosuppression, chronic rejection may still negate any early favourable results. This article will outline the clinical experience of CTA, the major problems of the technique and the potential solutions to these problems. (C) 2004 The British Association of Plastic Surgeons. Published by Elsevier Ltd. All rights reserved.

引用

页码：381 / 391

页数：11

共 35 条

[1] A position statement in support of hand transplantation [J].

Breidenbach, WC ;

Tobin, GR ;

Gorantla, VS ;

Gonzalez, RN ;

Granger, DK .

JOURNAL OF HAND SURGERY-AMERICAN VOLUME, 2002, 27A (05) :760-770

[2] Prope tolerance, perioperative campath 1H, and low-dose cyclosporin monotherapy in renal allograft recipients [J].

Calne, R ;

Friend, P ;

Moffatt, S ;

Bradley, A ;

Hale, G ;

Firth, J ;

Bradley, J ;

Smith, K ;

Waldmann, H .

LANCET, 1998, 351 (9117) :1701-1702

[3] Malignancies complicating organ transplantation [J].

First, MR ;

Peddi, VR .

TRANSPLANTATION PROCEEDINGS, 1998, 30 (06) :2768-2770

[4] Infection in organ-transplant recipients [J].

Fishman, JA ;

Rubin, RH .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (24) :1741-1751

[5]

Francois CG, 2000, MICROSURG, V20, P360, DOI 10.1002/1098-2752(2000)20:8<360::AID-MICR4>3.3.CO

[6]

2-5

[7]

Gilbert R., 1964, MED TRIB MED NEWS, V5, P23

[8] Major replantation versus revision amputation and prosthetic fitting in the upper extremity: A late functional outcomes study [J].

Graham, B ;

Adkins, P ;

Tsai, TM ;

Firrell, J ;

Breidenbach, WC .

JOURNAL OF HAND SURGERY-AMERICAN VOLUME, 1998, 23A (05) :783-791

[9] HUMAN ALLOTRANSPLANT OF A DIGITAL FLEXION SYSTEM VASCULARIZED ON THE ULNAR PEDICLE - A PRELIMINARY-REPORT AND 1-YEAR FOLLOW-UP OF 2 CASES [J].

GUIMBERTEAU, JC ;

BAUDET, J ;

PANCONI, B ;

BOILEAU, R ;

POTAUX, L .

PLASTIC AND RECONSTRUCTIVE SURGERY, 1992, 89 (06) :1135-1147

[10] Tolerance to composite tissue allografts across a major histocompatibility barrier in miniature swine [J].

Hettiaratchy, S ;

Melendy, E ;

Randolph, MA ;

Coburn, RC ;

Neville, DM ;

Sachs, DH ;

Huang, CA ;

Lee, WPA .

TRANSPLANTATION, 2004, 77 (04) :514-521

← 1 2 3 4 →