Direct to confusion: Lessons learned from marketing BRCA testing

被引：50

作者：

Matloff, Ellen ^{[1
]}

Caplan, Arthur ^{[2
]}

机构：

[1] Yale Canc Ctr, New Haven, CT 06520 USA

[2] Univ Penn, Philadelphia, PA 19104 USA

来源：

AMERICAN JOURNAL OF BIOETHICS | 2008年 / 8卷 / 06期

关键词：

BRCA1; BRCA2; genetic testing; hereditary breast and ovarian cancer; patents; monopoly; Myriad Genetics;

D O I：

10.1080/15265160802248179

中图分类号：

B82 [伦理学（道德学）];

学科分类号：

摘要：

Myriad Genetics holds a patent on testing for the hereditary breast and ovarian cancer genes, BRCA1 and BRCA2, and therefore has a forced monopoly on this critical genetic test. Myriad launched a Direct-to-Consumer (DTC) marketing campaign in the Northeast United States in September 2007 and plans to expand that campaign to Florida and Texas in 2008. The ethics of Myriad's patent, forced monopoly and DTC campaign will be reviewed, as well as the impact of this situation on patient access and care, physician liability, and the future of DTC campaigns for genetic testing.

引用

页码：5 / 8

页数：4

共 33 条

[1]

American College of Medicine Genetics Board of Directors, 2004, Genet Med, V6, P60

[2]

ANTONIOU A, 2000, CANC EPIDEMIOLOGY BI, V13, P2078

[3] Deficiency of knowledge of genetics and genetic tests among general practitioners, gynecologists, and pediatricians: A global problem [J].

Baars, MJH ;

Henneman, L ;

ten Kate, LP .

GENETICS IN MEDICINE, 2005, 7 (09) :605-610

[4]

CAPLAN AL, 2007, SMART MICE NOT SO SM

[5] Mortality after bilateral salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers:: a prospective cohort study [J].

Domchek, SM ;

Friebel, TM ;

Neuhausen, SL ;

Wagner, T ;

Evans, G ;

Isaacs, C ;

Garber, JE ;

Daly, M ;

Eeles, R ;

Matloff, E ;

Tomlinson, GE ;

Van't Veer, L ;

Lynch, HT ;

Olopade, O ;

Weber, BL ;

Rebbeck, TR .

LANCET ONCOLOGY, 2006, 7 (03) :223-229

[6] RISKS OF CANCER IN BRCA1-MUTATION CARRIERS [J].

FORD, D ;

EASTON, DF ;

BISHOP, DT ;

NAROD, SA ;

GOLDGAR, DE ;

HAITES, N ;

MILNER, B ;

ALLAN, L ;

PONDER, BAJ ;

PETO, J ;

SMITH, S ;

STRATTON, M ;

LENOIR, GM ;

FEUNTEUN, J ;

LYNCH, H ;

ARASON, A ;

BARKARDOTTIR, R ;

EGILSSON, V ;

BLACK, DM ;

KELSELL, D ;

SPURR, N ;

DEVILEE, P ;

CORNELISSE, CJ ;

VARSEN, H ;

BIRCH, JM ;

SKOLNICK, M ;

SANTIBANEZKOREF, MS ;

TEARE, D ;

STEEL, M ;

PORTER, D ;

COHEN, BB ;

CAROTHERS, A ;

SMYTH, E ;

WEBER, B ;

NEWBOLD, B ;

BOEHNKE, M ;

COLLINS, FS ;

CANNONALBRIGHT, LA ;

GOLDGAR, D .

LANCET, 1994, 343 (8899) :692-695

[7] The use and interpretation of commercial APC gene testing for familial adenomatous polyposis [J].

Giardiello, FM ;

Brensinger, JD ;

Petersen, GM ;

Luce, MC ;

Hylind, LM ;

Bacon, JA ;

Booker, SV ;

Parker, RD ;

Hamilton, SR .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (12) :823-827

[8] Limitations of direct-to-consumer advertising for clinical genetic testing [J].

Gollust, SE ;

Hull, SC ;

Wilfond, BS .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (14) :1762-1767

[9] Direct-to-consumer marketing of genetic tests for cancer: Buyer beware [J].

Gray, S .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (17) :3191-3193

[10] LINKAGE OF EARLY-ONSET FAMILIAL BREAST-CANCER TO CHROMOSOME-17Q21 [J].

HALL, JM ;

LEE, MK ;

NEWMAN, B ;

MORROW, JE ;

ANDERSON, LA ;

HUEY, B ;

KING, MC .

SCIENCE, 1990, 250 (4988) :1684-1689

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