Role of Pit-1 in the gene expression of growth hormone, prolactin, and thyrotropin

被引：124

作者：

Cohen, LE ^{[1
]}

Wondisford, FE ^{[1
]}

Radovick, S ^{[1
]}

机构：

[1] BETH ISRAEL HOSP, DEPT MED, DIV ENDOCRINOL, BOSTON, MA 02215 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 1996年 / 25卷 / 03期

关键词：

D O I：

10.1016/S0889-8529(05)70339-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pit-1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals. Pit-1 is important for the activation of the growth hormone and prolactin genes and for the hormonal regulation of the prolactin and thyrotropin-beta subunit genes. Mutation of the Pit-1 gene have been found in dwarf mouse strains displaying hypoplasia of growth hormone, prolactin, and thyrotropin-beta subunit through various molecular mechanisms.

引用

页码：523 / +

页数：1

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