Neurohormonal Axis in Patients with Pulmonary Arterial Hypertension Friend or Foe?

被引：69

作者：

de Man, Frances S. ^{[1
,2
]}

Handoko, M. Louis ^{[1
,2
]}

Guignabert, Christophe ^{[3
,4
]}

Bogaard, Harm J. ^{[1
]}

Vonk-Noordegraaf, Anton ^{[1
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Pulmonol, Inst Cardiovasc Res, NL-1081 HV Amsterdam, Netherlands

[2] Vrije Univ Amsterdam Med Ctr, Dept Physiol, Inst Cardiovasc Res, NL-1081 HV Amsterdam, Netherlands

[3] Ctr Chirurg Marie Lannelongue, INSERM, UMR 999, LabEx LERMIT, Le Plessis Robinson, France

[4] Univ Paris Sud, Sch Med, Le Kremlin Bicetre, France

来源：

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2013年 / 187卷 / 01期

关键词：

pulmonary hypertension; sympathetic nervous system; renin-angiotensin system; ANGIOTENSIN-CONVERTING ENZYME; RIGHT HEART-FAILURE; VENTRICULAR DYSFUNCTION; RECEPTOR; EXERCISE; RATS; CAPTOPRIL; SYSTEM; MONOCROTALINE; ACTIVATION;

D O I：

10.1164/rccm.201209-1663PP

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Despite its description some 25 years ago, neurohormonal activation has long been neglected as an important factor in the pathophysiology of pulmonary arterial hypertension (PAH). Neurohormonal activation was interpreted as a necessary compensatory response to maintain cardiac contractility and systemic blood pressure. Therefore, inhibitors of neurohormonal activity (like beta-blockers or angiotensin-converting enzyme inhibitors) are considered contraindicated in current PAH management guidelines. However, recent data revealed that sympathetic overstimulation is strongly related to mortality, and blockade of neurohormonal activity in experimental PAH improved survival and cardiac function. These novel insights shed new light on the role of neurohormonal activity in PAH.

引用

收藏

页码：14 / 19

页数：6

相关论文

共 51 条

[1] Angiotensin-converting enzyme DD genotype in patients with primary pulmonary hypertension: increased frequency and association with preserved haemodynamics [J].

Abraham, WT ;

Raynolds, MV ;

Badesch, DB ;

Wynne, KM ;

Groves, BM ;

Roden, RL ;

Robertson, AD ;

Lowes, BD ;

Zisman, LS ;

Voelkel, NF ;

Bristow, MR ;

Perryman, MB .

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2003, 4 (01) :27-30

[2] SHORT-TERM AND LONG-TERM HEMODYNAMIC-EFFECTS OF CAPTOPRIL IN PATIENTS WITH PULMONARY-HYPERTENSION AND SELECTED CONNECTIVE-TISSUE DISEASE [J].

ALPERT, MA ;

PRESSLY, TA ;

MUKERJI, V ;

LAMBERT, CR ;

MUKERJI, B .

CHEST, 1992, 102 (05) :1407-1412

[3] Adrenergic Receptor Blockade Reverses Right Heart Remodeling and Dysfunction in Pulmonary Hypertensive Rats [J].

Bogaard, Harm J. ;

Natarajan, Ramesh ;

Mizuno, Shiro ;

Abbate, Antonio ;

Chang, Philip J. ;

Chau, Vinh Q. ;

Hoke, Nicholas N. ;

Kraskauskas, Donatas ;

Kasper, Michael ;

Salloum, Fadi N. ;

Voelkel, Norbert F. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 182 (05) :652-660

[4] BETA-1-ADRENERGIC-RECEPTOR AND BETA-2-ADRENERGIC-RECEPTOR SUBPOPULATIONS IN NONFAILING AND FAILING HUMAN VENTRICULAR MYOCARDIUM - COUPLING OF BOTH RECEPTOR SUBTYPES TO MUSCLE-CONTRACTION AND SELECTIVE BETA-1-RECEPTOR DOWN-REGULATION IN HEART-FAILURE- [J].

BRISTOW, MR ;

GINSBURG, R ;

UMANS, V ;

FOWLER, M ;

MINOBE, W ;

RASMUSSEN, R ;

ZERA, P ;

MENLOVE, R ;

SHAH, P ;

JAMIESON, S ;

STINSON, EB .

CIRCULATION RESEARCH, 1986, 59 (03) :297-309

[5] Polymorphism in the Angiotensin II Type 1 Receptor (AGTR1) is Associated With Age at Diagnosis in Pulmonary Arterial Hypertension [J].

Chung, Wendy K. ;

Deng, Liyong ;

Carroll, J. Sheila ;

Mallory, Nicole ;

Diamond, Beverly ;

Rosenzweig, Erika Berman ;

Barst, Robyn J. ;

Morse, Jane H. .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2009, 28 (04) :373-379

[6] Atrial septostomy decreases sympathetic overactivity in pulmonary arterial hypertension [J].

Ciarka, Agnieszka ;

Vachiery, Jean-Luc ;

Houssiere, Anne ;

Gujic, Marko ;

Stoupel, Eric ;

Velez-Roa, Sonia ;

Naeije, Robert ;

van de Borne, Philippe .

CHEST, 2007, 131 (06) :1831-1837

[7] Prognostic Significance of Sympathetic Nervous System Activation in Pulmonary Arterial Hypertension [J].

Ciarka, Agnieszka ;

Doan, Vi ;

Velez-Roa, Sonia ;

Naeije, Robert ;

van de Borne, Philippe .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 181 (11) :1269-1275

[8] Effects of exercise training in patients with idiopathic pulmonary arterial hypertension [J].

de Man, F. S. ;

Handoko, M. L. ;

Groepenhoff, H. ;

van't Hul, A. J. ;

Abbink, J. ;

Koppers, R. J. H. ;

Grotjohan, H. P. ;

Twisk, J. W. R. ;

Bogaard, H-J. ;

Boonstra, A. ;

Postmus, P. E. ;

Westerhof, N. ;

van der Laarse, W. J. ;

Vonk-Noordegraaf, A. .

EUROPEAN RESPIRATORY JOURNAL, 2009, 34 (03) :669-675

[9] Dysregulated Renin-Angiotensin-Aldosterone System Contributes to Pulmonary Arterial Hypertension [J].

de Man, Frances S. ;

Tu, Ly ;

Handoko, M. Louis ;

Rain, Silvia ;

Ruiter, Gerrina ;

Francois, Charlene ;

Schalij, Ingrid ;

Dorfmueller, Peter ;

Simonneau, Gerald ;

Fadel, Elie ;

Perros, Frederic ;

Boonstra, Anco ;

Postmus, Piet E. ;

van der Velden, Iolanda ;

Vonk-Noordegraaf, Anton ;

Humbert, Marc ;

Eddahibi, Saadia ;

Guignabert, Christophe .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 186 (08) :780-789

[10] Bisoprolol Delays Progression Towards Right Heart Failure in Experimental Pulmonary Hypertension [J].

de Man, Frances S. ;

Handoko, M. Louis ;

van Ballegoij, Joris J. M. ;

Schalij, Ingrid ;

Bogaards, Sylvia J. P. ;

Postmus, Pieter E. ;

van der Velden, Jolanda ;

Westerhof, Nico ;

Paulus, Walter J. ;

Vonk-Noordegraaf, Anton .

CIRCULATION-HEART FAILURE, 2012, 5 (01) :97-U211

← 1 2 3 4 5 6 →