Improved synthesis for the rodenticides, diphenacoum and brodifacoum

被引：20

作者：

vanHeerden, PS ^{[1
]}

Bezuidenhoudt, BCB ^{[1
]}

Ferreira, D ^{[1
]}

机构：

[1] UNIV ORANGE FREE STATE,DEPT CHEM,ZA-9300 BLOEMFONTEIN,SOUTH AFRICA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1997年 / 08期

关键词：

D O I：

10.1039/a607269k

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

An improved synthesis of the 3-[3-(p-substituted phenyl)-1,2,3,4-tetrahydro-1-napththyl]-4-hydroxycoumarins, diphenacoum and brodifacoum, is described. The process is primarily based on the formation of one of the crucial bonds in the carbon backbone using organocopper methodology, and on the coupling of the 4-hydroxycoumarin moiety to the 3-biphenyl tetralin unit under strongly acidic conditions.

引用

页码：1141 / 1146

页数：6

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