Elevated plasma endothelin-1 and cytokine levels in children with severe acute respiratory distress syndrome

被引：23

作者：

Dobyns, EL

Eells, PL

Griebel, JL

Abman, SH

机构：

[1] Univ Colorado, Sch Med, Pediat Heart Lung Ctr, Pediat Crit Care Sect,Dept Pediat, Denver, CO 80202 USA

[2] Univ Colorado, Sch Med, Pediat Heart Lung Ctr, Sect Pulm Med,Dept Pediat, Denver, CO 80202 USA

来源：

JOURNAL OF PEDIATRICS | 1999年 / 135卷 / 02期

关键词：

D O I：

10.1016/S0022-3476(99)70029-6

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We performed serial measurements of plasma endothelin-1 and cytokine levels (interleukin-1, interleukin-6 and tumor necrosis factor-alpha) in 23 children with severe acute respiratory distress syndrome during their first 7 days of disease. We report plasma endothelin-1 and interleukin-6 levels are increased in patients with acute respiratory distress syndrome, and that plasma endothelin-1 levels are significantly greater early in the clinical course of nonsurvivors than survivors, We conclude that plasma endothelin-l levels are markedly increased in children with severe acute respiratory distress syndrome and speculate that high levels may serve as an early marker of poor outcome.

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收藏

页码：246 / 249

页数：4

相关论文

共 10 条

[1] ACUTE EFFECTS OF INHALED NITRIC-OXIDE IN CHILDREN WITH SEVERE HYPOXEMIC RESPIRATORY-FAILURE [J].

ABMAN, SH ;

GRIEBEL, JL ;

PARKER, DK ;

SCHMIDT, JM ;

SWANTON, D ;

KINSELLA, JP .

JOURNAL OF PEDIATRICS, 1994, 124 (06) :881-888

[2] PROSPECTIVE, RANDOMIZED COMPARISON OF HIGH-FREQUENCY OSCILLATORY VENTILATION AND CONVENTIONAL MECHANICAL VENTILATION IN PEDIATRIC RESPIRATORY-FAILURE [J].

ARNOLD, JH ;

HANSON, JH ;

TOROFIGUERO, LO ;

GUTIERREZ, J ;

BERENS, RJ ;

ANGLIN, DL .

CRITICAL CARE MEDICINE, 1994, 22 (10) :1530-1539

[3] ADULT-RESPIRATORY-DISTRESS-SYNDROME IN CHILDREN - ASSOCIATED DISEASE, CLINICAL COURSE, AND PREDICTORS OF DEATH [J].

DAVIS, SL ;

FURMAN, DP ;

COSTARINO, AT .

JOURNAL OF PEDIATRICS, 1993, 123 (01) :35-45

[4] ENDOTHELIN-1 IN ACUTE LUNG INJURY AND THE ADULT-RESPIRATORY-DISTRESS-SYNDROME [J].

LANGLEBEN, D ;

DEMARCHIE, M ;

LAPORTA, D ;

SPANIER, AH ;

SCHLESINGER, RD ;

STEWART, DJ .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 148 (06) :1646-1650

[5] PERSISTENT ELEVATION OF INFLAMMATORY CYTOKINES PREDICTS A POOR OUTCOME IN ARDS - PLASMA IL-1-BETA AND IL-6 LEVELS ARE CONSISTENT AND EFFICIENT PREDICTORS OF OUTCOME OVER TIME [J].

MEDURI, GU ;

HEADLEY, S ;

KOHLER, G ;

STENTZ, F ;

TOLLEY, E ;

UMBERGER, R ;

LEEPER, K .

CHEST, 1995, 107 (04) :1062-1073

[6] Endothelins and the lung [J].

Michael, JR ;

Markewitz, BA .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 154 (03) :555-581

[7] Biological markers of acute lung injury: Prognostic and pathogenetic significance [J].

Pittet, JF ;

Mackersie, RC ;

Martin, TR ;

Matthay, MA .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1997, 155 (04) :1187-1205

[8] TUMOR NECROSIS FACTOR CAUSES INCREASED PULMONARY PERMEABILITY AND EDEMA - COMPARISON TO SEPTIC ACUTE LUNG INJURY [J].

STEPHENS, KE ;

ISHIZAKA, A ;

LARRICK, JW ;

RAFFIN, TA .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1988, 137 (06) :1364-1370

[9] HIGH BRONCHOALVEOLAR LEVELS OF TUMOR-NECROSIS-FACTOR AND ITS INHIBITORS, INTERLEUKIN-1, INTERFERON, AND ELASTASE, IN PATIENTS WITH ADULT RESPIRATORY-DISTRESS SYNDROME AFTER TRAUMA, SHOCK, OR SEPSIS [J].

SUTER, PM ;

SUTER, S ;

GIRARDIN, E ;

ROUXLOMBARD, P ;

GRAU, GE ;

DAYER, JM .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 145 (05) :1016-1022

[10] MORTALITY-RATES AND PROGNOSTIC VARIABLES IN CHILDREN WITH ADULT RESPIRATORY-DISTRESS SYNDROME [J].

TIMMONS, OD ;

DEAN, JM ;

VERNON, DD .

JOURNAL OF PEDIATRICS, 1991, 119 (06) :896-899