Excess mortality associated with antimicrobial drug-resistant Salmonella typhimurium

被引:269
作者
Helms, M [1 ]
Vastrup, P [1 ]
Gerner-Smidt, P [1 ]
Molbak, K [1 ]
机构
[1] Statens Serum Inst, DK-2300 Copenhagen S, Denmark
关键词
D O I
10.3201/eid0805.010267
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In a matched cohort study, we determined the death rates associated with drug resistance in Salmonella Typhimurium. We linked data from the Danish Surveillance Registry for Enteric Pathogens with the Civil Registration System and the Danish National Discharge Registry. By survival analysis, the 2-year death rates were compared with a matched sample of the general Danish population, after the data were adjusted for differences in comorbidity. In 2,047 patients with S. Typhimurium, 59 deaths were identified. Patients with pansusceptible strains of S. Typhimurium were 2.3 times more likely to die 2 years after infection than persons in the general Danish population. Patients infected with strains resistant to ampicillin, chloramphenicol, streptomycin, sulfonamide, and tetracycline were 4.8 times (95% Cl 2.2 to 10.2) more likely to die, whereas quinolone resistance was associated with a mortality rate 10.3 times higher than the general population.
引用
收藏
页码:490 / 495
页数:6
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