Inclusion compounds of psychotropic agents and cyclodextrins

被引：8

作者：

Andronati, SA

Shapiro, YE

Yakubovskaya, LN

Gorbatyuk, VY

Andronati, KS

Krasnoschekaya, SP

机构：

[1] A. V. Bogatsky Phys.-Chem. Institute, Natl. Academy of Sciences of Ukraine, Odessa 270080

来源：

JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY | 1996年 / 24卷 / 1-2期

关键词：

psychotropic agents; cyclodextrins; phenazepam; cinazepam; inclusion compounds; structure; H-1-NMR spectroscopy; NOESY spectra; d-contacts; Nuclear Overhauser effect;

D O I：

10.1007/BF01053430

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Literature data on inclusion compounds of psychotropic agents (hypno-sedative, anticonvulsive and antiepileptic drugs, neuroleptics and anxiolytics) with cyclodextrins and their derivatives are presented. Inclusion compounds of two novel psychotropic agents, gidazepam and cinazepam, with beta-cyclodextrin (1 : 1 and 1 : 2) were obtained. The structure of these complexes has been established by one- and two-dimensional H-1-NMR (for solutions in DMSO) and IR (for solid slate) spectroscopy.

引用

页码：175 / 186

页数：12

共 14 条

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ABDELRAHMAN AA, 1994, J PHARM BELG, V49, P23

[2] COMPLEX-FORMATION OF NITRAZEPAM IN COPRECIPITATING AND IN CO-GRINDING WITH METHYLATED BETA-CYCLODEXTRINS [J].