Tim-3, a negative regulator of anti-tumor immunity

被引：182

作者：

Anderson, Ana Carrizosa ^{[1
,2
]}

机构：

[1] Brigham & Womens Hosp, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 02期

关键词：

T-CELL EXHAUSTION; MELANOMA PATIENTS; APOPTOTIC CELLS; STEM-CELLS; PHASE-I; PD-1; PHAGOCYTOSIS; PERSISTENCE; PROGRESSION; EXPRESSION;

D O I：

10.1016/j.coi.2011.12.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

T cell immunoglobulin-3 (Tim-3) was identified nearly 10 years ago as a negative regulator of IFN-gamma-secreting CD4(+) T helper 1 and CD8(+) T cytotoxic 1 cells. Tim-3 is now classed with other inhibitory receptors, such as cytotoxic lymphocyte antigen-4 and programmed death-1 that are commonly referred to as immune checkpoint molecules Recent studies have highlighted Tim-3 as an important player in the CD8(+) T cell exhaustion that takes place in chronic immune conditions such as chronic viral infection and cancer in both humans and experimental models. In addition to its role in exhausted T cells, recent data suggest that Tim-3 can further influence cancer outcome through its action on myeloid cells and cancer stem cells.

引用

页码：213 / 216

页数：4

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