Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum

被引：53

作者：

Afzal, Muhammad ^{[1
]}

Gupta, Gaurav ^{[1
]}

Kazmi, Imran ^{[1
]}

Rahman, Mahfoozur ^{[2
]}

Afzal, Obaid ^{[3
]}

Alam, Jahangir ^{[3
]}

Hakeem, Khalidur Rahman ^{[3
]}

Pravez, Mohammad ^{[3
]}

Gupta, Ritu ^{[4
]}

Anwar, Firoz ^{[1
]}

机构：

[1] Siddhartha Inst Pharm, Dehra Dun, Uttarakhand, India

[2] Dreamz Coll Pharm, Khilra, Himachal Prades, India

[3] Jamia Hamdard, New Delhi, India

[4] Bharat Inst Technol, Meerut, Uttar Pradesh, India

来源：

FITOTERAPIA | 2012年 / 83卷 / 05期

关键词：

Bryophyllum pinnatum; Isolation; Characterization; Steroidal derivative; Anti-inflammatory; Analgesic; KALANCHOE-PINNATA; AQUEOUS EXTRACT; LEAVES; GLYCOSIDE; OKEN;

D O I：

10.1016/j.fitote.2012.03.013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new steroidal derivative, urs Stigmast-4, 20 (21), 23-trien-3-one and other four compounds were isolated from the leaves of Bryophyllum pinnatum. The structure of this new steroid was elucidated and established by standard spectroscopic methods. Carrageenan induced paw edema model was used for anti-inflammatory and acetic acid induced model used for analgesic activity. This new steroidal compound was found to be active in reducing inflammation (% inhibition 87.29 and 84.45 respectively) when compared with diclofenac. Further, it showed 75.72% protection in analgesic activity in acetic acid induced writhing test in mice. In conclusion the % inhibition against carrageenan induced rat paw edema and % protection against acetic acid induced writhings showed by new compound revealed that the anti-inflammatory and analgesic activity of aqueous extract B. pinnatum are mainly due to the presence of this steroidal compound. Crown Copyright (C) 2012 Published by Elsevier B.V. All rights reserved.

引用

页码：853 / 858

页数：6

共 29 条

[1] Antimicrobial activity of Bryophyllum pinnatum leaves [J].

Akinpelu, DA .

FITOTERAPIA, 2000, 71 (02) :193-194

[2] Bioactive molecules in Kalanchoe pinnata leaves: extraction, purification, and identification [J].

El Abdellaoui, Saida ;

Destandau, Emilie ;

Toribio, Alix ;

Elfakir, Claire ;

Lafosse, Michel ;

Renimel, Isabelle ;

Andre, Patrice ;

Cancellieri, Perrine ;

Landemarre, Ludovic .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2010, 398 (03) :1329-1338

[3] ANTI-INFLAMMATORY ACTIVITY OF STEROID ALKALOID GLYCOSIDE, TOMATINE [J].

FILDERMA.RB ;

KOVACS, BA .

BRITISH JOURNAL OF PHARMACOLOGY, 1969, 37 (03) :748-&

[4] PHENOLIC COMPONENTS FROM LEAVES OF KALANCHOE-PINNATA [J].

GAIND, KN ;

GUPTA, RL .

PLANTA MEDICA, 1973, 23 (02) :149-153

[5] RADICAL SCAVENGING POTENTIAL OF PHENOLICS FROM Bryophyllum pinnatum (LAM.) OKEN [J].

Gupta, Suneel ;

Banerjee, Rintu .

PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY, 2011, 41 (03) :305-319

[6]

Khandelwal KR., 2008, PRACTICAL PHARMACOGN, P149

[7]

Khare CP, 2004, ENCY INDIAN MEDICINA, V4, P276

[8]

Kirtikar KR, 2000, INDIAN MED PLANTS, V2, P1511

[9]

KOSTER R, 1959, FED PROC, V18, P412

[10] Ethnomedicines used in Trinidad and Tobago for urinary problems and diabetes mellitus [J].

Lans, Cheryl A. .

JOURNAL OF ETHNOBIOLOGY AND ETHNOMEDICINE, 2006, 2 (1)

← 1 2 3 →