Molecular basis of localized responses during chemotaxis in amoebae and leukocytes

被引：33

作者：

van Es, S ^{[1
]}

Devreotes, PN ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 1999年 / 55卷 / 10期

关键词：

chemotaxis; Dictyostelium; leukocytes; chemoattractant receptors; G-proteins; signal transduction;

D O I：

10.1007/s000180050374

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Free-living amoebae as well as mammalian leukocytes sense chemoattractants with seven helix receptors linked to G-proteins. The cells respond by extending pseudopods and moving in the direction of the highest concentration. Recent studies using GFP-tagged proteins in Dietyostelium have shown that the directional response becomes sharply localized downstream of the receptors and G-proteins but upstream of the actin cytoskeleton. These studies together with the isolation novel genes by insertional mutagenesis in Dictyostelium are leading to a new understanding of chemotaxis in eucaryotic cells.

引用

页码：1341 / 1351

页数：11

共 69 条

[1] Dictyostelium myosin II is regulated during chemotaxis by a novel protein kinase C
AbuElneel, K
Karchi, M
Ravid, S
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (02) : 977 - 984
[2] AMATRUDA TT, 1993, J BIOL CHEM, V268, P10139
[3] A DICTYOSTELIUM MUTANT DEFICIENT IN SEVERIN, AN F-ACTIN FRAGMENTING PROTEIN, SHOWS NORMAL MOTILITY AND CHEMOTAXIS
ANDRE, E
BRINK, M
GERISCH, G
ISENBERG, G
NOEGEL, A
SCHLEICHER, M
SEGALL, JE
WALLRAFF, E
[J]. JOURNAL OF CELL BIOLOGY, 1989, 108 (03) : 985 - 995
[4] Dissociation of chemotaxis from agonist-induced receptor internalization in a lymphocyte cell line transfected with CCR2B - Evidence that directed migration does not require rapid modulation of signaling at the receptor level
Arai, H
Monteclaro, FS
Tsou, CL
Franci, C
Charo, IF
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (40) : 25037 - 25042
[5] THE INHIBITION OF NEUTROPHIL GRANULE ENZYME-SECRETION AND CHEMOTAXIS BY PERTUSSIS TOXIN
BECKER, EL
KERMODE, JC
NACCACHE, PH
YASSIN, R
MARSH, ML
MUNOZ, JJ
SHAAFI, RI
[J]. JOURNAL OF CELL BIOLOGY, 1985, 100 (05) : 1641 - 1646
[6] Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases
Becker, W
Weber, Y
Wetzel, K
Eirmbter, K
Tejedor, FJ
Joost, HG
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (40) : 25893 - 25902
[7] Phagocyte chemoattractant receptors
Boulay, F
Naik, N
Giannini, E
Tardif, M
Brouchon, L
[J]. PHAGOCYTES: BIOLOGY, PHYSIOLOGY, PATHOLOGY, AND PHARMACOTHERAPEUTICS, 1997, 832 : 69 - 84
[8] Molecular characterization of a Dictyostelium G-protein alpha-subunit required for development
Brandon, MA
Voglmaier, S
Siddiqi, AA
[J]. GENE, 1997, 200 (1-2) : 99 - 105
[9] NEUTROPHIL AND B-CELL EXPANSION IN MICE THAT LACK THE MURINE IL-8 RECEPTOR HOMOLOG
CACALANO, G
LEE, J
KIKLY, K
RYAN, AM
PITTSMEEK, S
HULTGREN, B
WOOD, WI
MOORE, MW
[J]. SCIENCE, 1994, 265 (5172) : 682 - 684
[10] ISOZYME-SELECTIVE STIMULATION OF PHOSPHOLIPASE C-BETA-2 BY G-PROTEIN BETA-GAMMA-SUBUNITS
CAMPS, M
CAROZZI, A
SCHNABEL, P
SCHEER, A
PARKER, PJ
GIERSCHIK, P
[J]. NATURE, 1992, 360 (6405) : 684 - 686

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