Gene transcription in trypanosomes

被引：102

作者：

Palenchar, JB ^{[1
]}

Bellofatto, V ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Microbiol & Mol Genet, Int Ctr Publ Hlth, Newark, NJ 07103 USA

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 2006年 / 146卷 / 02期

关键词：

RNA polymerases; trypanosomes; basal transcription factors;

D O I：

10.1016/j.molbiopara.2005.12.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Trypanosoma brucei and the other members of the trypanosomatid family of parasitic protozoa, contain an unusual RNA polymerase II enzyme, uncoordinated mRNA 5' capping and transcription initiation events, and most likely contain an abridged set of transcription factors. Pre-mRNA start sites remain elusive. In addition, two important life cycle stage-specific mRNAs are transcribed by RNA polymerase I. This review interprets these unusual transcription traits in the context of parasite biology. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：135 / 141

页数：7

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