Potassium channels as tumour markers

被引：81

作者：

Stuehmer, Walter

Alves, Frauke

Hartung, Franziska

Zientkowska, Marta

Pardo, Luis A.

机构：

[1] Max Planck Inst Expt Med, D-37075 Gottingen, Germany

[2] Univ Gottingen, Dept Hematol & Oncol, D-37075 Gottingen, Germany

来源：

FEBS LETTERS | 2006年 / 580卷 / 12期

关键词：

EAG; cancer; ion channels; oncogene; near-infrared imaging;

D O I：

10.1016/j.febslet.2006.03.062

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An increasing number of ion channels are being found to be causally involved in diseases, giving rise to the new field of "channelopathies". Cancer is no exception, and several ion channels have been linked to tumour progression. Among them is the potassium channel EAG (Ether-a-go-go). Over 75% of tumours have been tested positive using a monoclonal antibody specific for EAG, while inhibition of this channel decreased the proliferation of EAG expressing cells. The inhibition of EAG is accomplished using RNA interference, functional anti-EAG1 antibodies, or (unspecific) EAG channel blockers. Fluorescently labelled recombinant Fab fragments recognizing EAG allow the distribution of EAG to be visualized in an in vivo mouse tumour model. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2850 / 2852

页数：3

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