The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer

被引：30

作者：

Barber, MD

McMillan, DC ^{[1
]}

Wallace, AM

Ross, JA

Preston, T

Fearon, KCH

机构：

[1] Univ Glasgow, Royal Infirm, Dept Surg, Glasgow G31 2ER, Lanark, Scotland

[2] Univ Edinburgh, Royal Infirm Edinburgh, Dept Surg, Edinburgh EH3 9YW, Midlothian, Scotland

[3] Royal Infirm, Dept Clin Biochem, Glasgow G31 2ER, Lanark, Scotland

[4] Scottish Univ Environm Res Ctr, Isotope Biochem Lab, Glasgow G75 0QF, Lanark, Scotland

来源：

BRITISH JOURNAL OF CANCER | 2004年 / 90卷 / 06期

关键词：

leptin; interleukin-6; insulin; cortisol; fat oxidation; feeding; weight loss; pancreatic cancer;

D O I：

10.1038/sj.bjc.6601712

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

At baseline, weight-losing pancreatic cancer patients (n = 7) had lower leptin (P < 0.05) but higher cortisol, interleukin-6, resting energy expenditure and fat oxidation than healthy subjects (n = 6, P < 0.05). Over a 4 h feeding period, the areas under the curve for glucose, cortisol and interleukin-6 were greater (P < 0.05), but less for leptin in the cancer group (P < 0.05). Therefore, it would appear that low leptin concentrations, increased fat oxidation and insulin resistance are associated with increased concentrations of cortisol and interleukin-6 in weight-losing patients with pancreatic cancer.

引用

收藏

页码：1129 / 1132

页数：4

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