A patient with treatment-resistant schizophrenia and cytochrome P4502D6 gene duplication

被引：7

作者：

Kawanishi, C ^{[1
]}

Furuno, T ^{[1
]}

Kishida, I ^{[1
]}

Matsumura, T ^{[1
]}

Kosaka, K ^{[1
]}

机构：

[1] Yokohama City Univ, Sch Med, Dept Psychiat, Yokohama, Kanagawa, Japan

来源：

CLINICAL GENETICS | 2002年 / 61卷 / 02期

关键词：

CYP2D6; gene duplication; pharmacogenetics; schizophrenia; treatment resistance; ultra-rapid metabolizer;

D O I：

10.1034/j.1399-0004.2002.610211.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We describe a patient with treatment-resistant schizophrenia who had a duplication in the cytochrome P450IID6 (CYP2D6) gene. This severely ill 71-year-old-woman had responded poorly to several neuroleptics. Molecular genetic study revealed CYP2D6 gene duplication, which results in excessive activity of CYP2D6 that metabolizes various commonly used neuroleptics. The mutation may have contributed to treatment resistance in this case.

引用

页码：152 / 154

页数：3

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