Nano-titanium dioxide enhanced biosensing of the interaction of dacarbazine with DNA and DNA bases

被引：44

作者：

Song, Min ^{[1
]}

Zhang, Renyun ^{[1
]}

Wang, Xuemei ^{[1
]}

机构：

[1] SE Univ, Chien Shiung Wu Lab, State Key Lab Bioelect, Nanjing 210096, Peoples R China

来源：

MATERIALS LETTERS | 2006年 / 60卷 / 17-18期

基金：

中国国家自然科学基金;

关键词：

titanium dioxide; nanomaterials; electrochemistry; biomolecular recognition; DNA;

D O I：

10.1016/j.matlet.2005.12.100

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The biomolecular binding behavior of anticancer drug dacarbazine (DTIC) in the presence of titanium dioxide (TiO2) nanoparticle interface has been studied by using electrochemical methods. The results indicate that the presence of TiO2 nanoparticles can obviously increase the binding affinity of DTIC to DNA or DNA bases and significantly enhance the detection sensitivity for the relative biomolecular recognition. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：2143 / 2147

页数：5

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