Changes with aging and ischemia in nicotinic acetylcholine receptor subunit α7 mRNA expression in postmortem human frontal cortex and putamen

被引：29

作者：

Utsugisawa, K

Nagane, Y

Tohgi, H

Yoshimura, M

Ohba, H

Genda, Y

机构：

[1] Iwate Med Univ, Dept Neurol, Morioka, Iwate 020, Japan

[2] Kyoto Municipal Univ, Dept Forens Med, Kyoto, Japan

来源：

NEUROSCIENCE LETTERS | 1999年 / 270卷 / 03期

关键词：

nicotinic acetylcholine receptor subunit alpha 7; cerebral cortex; putamen; aging; status lacunaris; reverse transcription polymerase chain reaction;

D O I：

10.1016/S0304-3940(99)00473-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Age-related changes in nicotinic acetylcholine receptor (nAChR) subunit alpha 7 messenger RNA (mRNA) expression in postmortem human frontal cortex and putamen of controls and status lacunaris patients were investigated using nonradioactive reverse transcripton (RT)-PCR. In the frontal cortex of control brains, alpha 7 subunit mRNA significantly decreased with age (P < 0.05). in the putamen, alpha 7 subunit mRNA expression was significantly lower than that in the frontal cortex(P < 0.0001), and showed no significant correlation with age. However, in cases with status lacunaris in the putamen, alpha 7 subunit mRNA expression was significantly higher compared with controls (P < 0.001). The reduction in alpha 7 nAChR in the frontal cortex with age may decrease functional cholinergic synapses and cortical activity, and play a role in the cognitive impairments associated with normal aging. The functional significance of the upregulation of alpha 7 nAChR mRNA in ischemic conditions remains to be determined. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：145 / 148

页数：4

共 27 条

[1] NICOTINE-INDUCED PROTECTION OF CULTURED CORTICAL-NEURONS AGAINST N-METHYL-D-ASPARTATE RECEPTOR-MEDIATED GLUTAMATE CYTOTOXICITY [J].