Synthesis and characterization of PLGA nanoparticles

被引:599
作者
Astete, Carlos E. [1 ]
Sabliov, Cristina M. [1 ]
机构
[1] Louisiana State Univ, Ctr Agr, Dept Biol & Agr Engn, Baton Rouge, LA 70803 USA
关键词
PLGA; nanoparticles; size; synthesis; characterization; emulsion evaporation;
D O I
10.1163/156856206775997322
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Poly(lactide-co-glycolide) (PLGA) nanoparticles of different physical characteristics (size, size distribution, morphology, zeta potential) can be synthesized by controlling the parameters specific to the synthesis method employed. The aim of this review is to clearly, quantitatively and comprehensively describe the top-down synthesis techniques available for PLGA nanoparticle formation. as well as the techniques commonly Used for nanoparticle characterization. Many examples are discussed in detail to provide the reader with an extensive knowledge base oil the important parameters specific to the synthesis method described and ways in which these parameters can be manipulated to control the nanoparticle physical characteristics.
引用
收藏
页码:247 / 289
页数:43
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