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α-Synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals

被引：107
作者：
Klos, KJ
Ahlskog, JE
Josephs, KA
Apaydin, H
Parisi, JE
Boeve, BF
DeLucia, MW
Dickson, DW
机构：
[1] Mayo Clin, Dept Neurosci & Neuropathol, Jacksonville, FL 32224 USA
[2] Mayo Clin, Dept Neurol, Rochester, MN USA
[3] Mayo Clin, Dept Lab Med, Rochester, MN USA
[4] Mayo Clin, Dept Pathol, Rochester, MN USA
[5] Istanbul Univ, Dept Neurol, Cerrahpasa Med Sch, Istanbul, Turkey
来源：
NEUROLOGY | 2006年 / 66卷 / 07期
关键词：
D O I：
10.1212/01.wnl.0000204179.88955.fa
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The authors assessed the frequency of spinal cord alpha-synuclein pathology in neurologically asymptomatic individuals older than 60 years of age ( N = 106). Using alpha-synuclein immunohistochemistry, nine cases (8%) had incidental Lewy neurites in the intermediolateral column and at least some alpha-synuclein pathology in the dorsal motor nucleus of the vagus, locus ceruleus, and central raphe nucleus. Sparse alpha-synuclein pathology was also detected in the substantia nigra, basal forebrain, amygdala, or cortex in all but two cases.
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页码：1100 / 1102
页数：3
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