Biosynthetic origin of the rare nitroaryl moiety of the polyketide antibiotic aureothin:: Involvement of an unprecedented N-oxygenase

被引：95

作者：

He, J ^{[1
]}

Hertweck, C ^{[1
]}

机构：

[1] Hans Knoll Inst Nat Prod Res, D-07745 Jena, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 12期

关键词：

D O I：

10.1021/ja039328t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The antibiotic aureothin is a rare natural nitroaromatic compound produced by Streptomyces thioluteus. By labeling experiments, we demonstrate for the first time that p-nitrobenzoate (PNBA) serves as a polyketide synthase starter unit. Cloning, heterologous expression, and inactivation experiments reveal that this unusual primer is synthesized from p-aminobenzoate (PABA) by means of AurF, a novel N-oxygenase. Copyright © 2004 American Chemical Society.

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页码：3694 / 3695

页数：2

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