Wound healing: An overview

被引:282
作者
Broughton, G [1 ]
Janis, JE
Attinger, CE
机构
[1] Univ Texas, SW Med Ctr, Dept Plast Surg, Nancy L & Perry Bass Adv Wound Healing Lab, Dallas, TX 75235 USA
[2] Georgetown Univ, Med Ctr, Georgetown Limb Ctr, Washington, DC 20057 USA
关键词
D O I
10.1097/01.prs.0000222562.60260.f9
中图分类号
R61 [外科手术学];
学科分类号
摘要
Learning Objectives: After studying this article, the participant should be able to: 1. Describe the actions of inflammatory mediators, growth factors, and nitric oxide involved in wound healing. 2. Describe the different cellular elements and their function in wound healing. 3. Discuss the three phases of wound healing and the relationships between mediators and cells for each. 4. Discuss the similarities and differences between keloids and hypertrophic scar and the treatment options for each. 5. Discuss the systemic and external factors involved in wound healing. 6. Discuss future wound-healing opportunities. Summary: Understanding wound healing today involves much more than simply stating that there are three phases: inflammation, proliferation, and maturation. Wound healing is a complex series of reactions and interactions among cells and "mediators." Each year, new mediators are discovered and our understanding of inflammatory mediators and cellular interactions grows. This article will attempt to provide a concise overview on wound healing and wound management.
引用
收藏
页码:294S / 294S
页数:1
相关论文
共 217 条
[1]
Serhan C., Chiang N., Novel endogenous small molecules as the checkpoint controllers in inflammation and resolution entrée for resolemics, Rheum. Dis. Clin. North Am., 30, (2004)
[2]
Schilling J., Wound healing, Surg. Clin. North Am., 56, (1976)
[3]
Henry G., Garner W., Inflammatory mediators in wound healing, Surg. Clin. North Am., 83, (2003)
[4]
Lawrence W., Diegelmann R., Growth factors in wound healing, Clin. Dermatol., 12, (1994)
[5]
Witte M., Barbul A., General principles of wound healing, Surg. Clin. North Am., 77, (1997)
[6]
Kurkinen M., Vaheri A., Roberts P., Et al., Sequential appearance of fibronectin and collagen in experimental granulation tissue, Lab. Invest., 43, (1980)
[7]
Martin P., Wound healing-aiming for perfect skin regeneration, Science, 276, (1997)
[8]
Pohlman T., Stanness K., Beatty P., Et al., An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin 1 and tumor necrosis factor-alpha increases neutrophil adherence by a CDw18-dependent mechanism, J. Immunol., 136, (1986)
[9]
Bevilacqua M., Pober J., Wheeler M., Et al., Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines, J. Clin. Invest., 76, (1985)
[10]
Witte M., Barbul A., Role of nitric oxide in wound repair, Am. J. Surg., 183, (2002)