Recombination hot spot of hepatitis B virus genome binds to members of the HMG domain protein family and the Y box binding protein family; Implication of these proteins in genomic instability

被引:17
作者
Kajino, K [1 ]
Yamamoto, T [1 ]
Hayashi, J [1 ]
Umeda, T [1 ]
Takahara, T [1 ]
Hino, O [1 ]
机构
[1] Japanese Fdn Canc Res, Inst Canc, Dept Expt Pathol, Toshima Ku, Tokyo 1708455, Japan
关键词
hepatocarcinogenesis; DNA recombination; hepatitis B virus; genomic instability;
D O I
10.1159/000050063
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Objective: Previously we hypothesized that the occurrence of hepatocellular carcinoma (HCC) is enhanced by genomic instability induced by the integrated hepatitis B virus (HBV) DNA. Using an in vitro recombination assay, we showed that a subgenomic fragment of HBV DNA designated 15AB (nt1855-1914) is indispensable for in vitro recombination, and also showed the existence of 15AB binding protein. On the assumption that the 15AB binding protein may be a candidate cellular recombinogenic protein which accelerates genomic instability and hepatocarcinogenesis, we tried to isolate it by southwestern screening. Results and Conclusion: We obtained several positive clones including mouse upstream binding factor (UBF) and DNA binding protein A (dbpA). UBF belongs to an HMG domain protein family and dbpA belongs to a Y box binding protein family. 15AB binding seemed to be mediated by the conserved DNA binding domains in these families, because other members in the families such as HMG1 and YB-1 also bound to 15AB. We report them here because several documents have already suggested the possible association of these families and DNA recombination. Copyright (C) 2001 S, Karger AG, Basel.
引用
收藏
页码:311 / 316
页数:6
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