The Japanese MCI screen for early detection of Alzheimer's disease and related disorders

Early detection of Alzheimer's disease and related disorders in Japan is increasingly important. The Mild In. Cognitive Impairment Screen (MCIS)-derived from the National Institute of Aging CERAD neuropsychologic batter)-differentiates normal aging from MCI and mild dementia with 97.3% and 99% accuracy, respectively. The Japanese MCIS (JMCIS), Mini-Mental State Examination (MMSE), quantitative SPECT (qSP), and quantitative MRI (qMRI) were used to classify 63 Outpatients at Fukuoka University Hospital who were either normal or bad MCI based on Clinical Dementia Rating scores of 0 and 0.5, respectively Performance statistics for the JMCIS, MMSE, qSP, and qMRI were, respectively: (1) accuracy = 0.964., 0.768, 0.722, 0.733; (2) sensitivity = 0.958, 0.792, 0.688, 0.700; (3) specificity = 1.000, 0.625, 1.000, 1.000; and (4) K validity = 0.813, 0.420, 0.296, 0.308. This initial study shows negligible differences between the English and Japanese MCIS, supporting its potential use for early detection in Japan.