Stability of fenbendazole suspensions for veterinary use Correlation between zeta potential and sedimentation

被引:20
作者
Arias, Jose L. [1 ]
Lopez-Viota, Margarita [1 ]
Clares, Beatriz [1 ]
Adolfina Ruiz, M. [1 ]
机构
[1] Univ Granada, Dept Farm & Tecnol Farmaceut, Fac Farm, E-18071 Granada, Spain
关键词
fenbendazole; influence of pH and electrolytes; sedimentation; stability; suspension; zeta potential; veterinary dosage forms;
D O I
10.1016/j.ejps.2008.04.008
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In this paper we have carried out a detailed investigation of the stability and redispersibility characteristics of fenbendazole aqueous suspensions, through a thermodynamic and electrokinetic characterization, considering the effect of both pH and ionic strength. The hydrophobic character of the dr-ug, and the surface charge and electrical double-layer thickness play an essential role in the stability of the system, hence the need for a full characterization of fenbendazole. It was found that the drug suspensions displays "delayed" or "hindered" sedimentation, determined by their hydrophobic character and their low zeta potential (indicating a small electrokinetic charge on the particles). The electrostatic repulsion between the particles is responsible for the low sedimentation volume and poor redispersibility of the drug. However, only low concentrations of AIC13 induced a significant effect on both the zeta potential and stability of the drug, leading to a "free-layered" sedimentation and a very easy redispersion which could be of great interest in the design of an oral pharmaceutical dosage form for veterinary. (c) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:257 / 262
页数:6
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