The Role of Telomeres in Stem Cells and Cancer

被引：194

作者：

Guenes, Cagatay ^{[1
]}

Rudolph, K. Lenhard ^{[1
]}

机构：

[1] Fritz Lipmann Inst, Leibniz Inst Age Res, D-07745 Jena, Germany

来源：

CELL | 2013年 / 152卷 / 03期

关键词：

CHROMOSOMAL INSTABILITY; SELF-RENEWAL; CHECKPOINTS; TRF1;

D O I：

10.1016/j.cell.2013.01.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomere shortening impairs proliferation of transformed cells but also leads to cancer initiation by inducing chromosomal instability. Here, we discuss recent developments in our understanding of the role of telomeres in replication stress and how telomerase expression in somatic stem cells may affect genome integrity control and carcinogenesis.

引用

页码：390 / 393

页数：4

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