Two closely linked interactive blood pressure QTL on rat chromosome 5 defined using congenic Dahl rats

被引：47

作者：

Garrett, MR ^{[1
]}

Rapp, JP ^{[1
]}

机构：

[1] Med Coll Ohio, Dept Physiol & Mol Med, Toledo, OH 43614 USA

来源：

PHYSIOLOGICAL GENOMICS | 2002年 / 8卷 / 02期

关键词：

hypertension; quantitative trait loci; genetic hypertension;

D O I：

10.1152/physiolgenomics.00080.2001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Previously we reported the construction of a congenic strain, S. LEW( 5), spanning a large region of rat chromosome 5. The Lewis (LEW) strain was the donor, and the Dahl salt-sensitive (S) strain was the recipient. The congenic strain included a blood pressure quantitative trait locus (QTL). In the present work, a series of nine congenic substrains were constructed from S. LEW( 5) which defined two closely linked blood pressure QTL in the region previously thought to contain only one. LEW low-blood-pressure alleles at both QTL were required for a major effect on blood pressure. Neither LEW allele alone had a significant effect on blood pressure. The two QTL were localized to regions 6.3 and 4.6 cM, and these were 1.0 cM apart.

引用

页码：81 / 86

页数：6

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