The hematopoietic stem cell niche-home for friend and foe?

被引：59

作者：

Krause, Daniela S. ^{[1
,2
,3
,4
]}

Scadden, David T. ^{[2
,3
,4
]}

Preffer, Frederic I. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

[4] Harvard Univ, Harvard Stem Cell Inst, Dept Stem Cell & Regenerat Biol, Boston, MA 02114 USA

来源：

CYTOMETRY PART B-CLINICAL CYTOMETRY | 2013年 / 84B卷 / 01期

关键词：

hematopoietic stem cell; bone marrow microenvironment; leukemia stem cell; flow cytometry; ACUTE MYELOID-LEUKEMIA; BONE-MARROW MICROENVIRONMENT; CHRONIC MYELOGENOUS LEUKEMIA; RECEPTOR-ALPHA CHAIN; E-SELECTIN LIGAND; MOUSE MODEL; OSTEOBLASTIC CELLS; INDUCED APOPTOSIS; PROGENITOR CELLS; MURINE MODEL;

D O I：

10.1002/cyto.b.21066

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The hematopoietic stem cell (HSC) niche is involved in the maintainance and regulation of quiescence, self-renewal and differentiation of hematopoietic stem cells and the fate of their progeny in mammals dealing with the daily stresses to the hematopoietic system. From the discovery that perturbations of the HSC niche can lead to hematopoietic disorders, we have now arrived at the prospect that the HSC niche may play a role in hematological malignancies and that this HSC niche may be a target for therapy. This review attempts to capture the discoveries of the last few years regarding the normal and malignant hematopoietic stem cell niche and possible ways to target this niche. (c) 2012 International Clinical Cytometry Society

引用

页码：7 / 20

页数：14

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