Urethane-induced somatostatin mediated inhibition of gastric acid:: Reversal by the somatostatin 2 receptor antagonist PRL-2903

被引：24

作者：

Kawakubo, K

Coy, DH

Walsh, JH

Taché, Y

机构：

[1] W Los Angeles Vet Affairs Med Ctr, CURE Digest Dis Res Ctr, Dept Med, Div Digest Dis, Los Angeles, CA 90073 USA

[2] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90073 USA

[3] Tulane Univ, Med Ctr, Dept Med, New Orleans, LA 70112 USA

来源：

LIFE SCIENCES | 1999年 / 65卷 / 10期

关键词：

somatostatin receptor antagonist; acid secretion; PRL-2903; somatostatin antibody;

D O I：

10.1016/S0024-3205(99)00340-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Urethane increases the release of somatostatin (SRIF) which inhibits gastric acid secretion. The SRIF monoclonal antibody, CURE.S6 and the novel sst(2) antagonist, PRL-2903 injected intravenously at maximal effective doses increased gastric acid secretion by 2 and 10 fold respectively from basal values within 30 min in urethane-anesthetized rats. Plasma gastrin levels were elevated 2.5 fold within 15 min by PRL-2903 (1.3 mu mol/kg, iv). These data indicate that the low gastrin and acid secretion levels induced by urethane result from endogenous SRIF acting on sst(2) and that PRL-2903 is a valuable SRIF antagonist to assess sst(2) mediated events. (C) 1999 Elsevier Science Inc.

引用

页码：PL115 / PL120

页数：6

共 20 条

[1]

Aurang K, 1997, J PHARMACOL EXP THER, V281, P245

[2] A linear hexapeptide somatostatin antagonist blocks somatostatin activity in vitro and influences growth hormone release in rats [J].

Baumbach, WR ;

Carrick, TA ;

Pausch, MH ;

Bingham, B ;

Carmignac, D ;

Robinson, ICAF ;

Houghten, R ;

Eppler, CM ;

Price, LA ;

Zysk, JR .

MOLECULAR PHARMACOLOGY, 1998, 54 (05) :864-873

[3]

HAKANSON R, 1994, YALE J BIOL MED, V67, P123

[4] Potent antagonists of somatostatin: Synthesis and biology [J].

Hocart, SJ ;

Jain, R ;

Murphy, WA ;

Taylor, JE ;

Morgan, B ;

Coy, DH .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (07) :1146-1154

[5] CLASSIFICATION AND NOMENCLATURE OF SOMATOSTATIN RECEPTORS [J].

HOYER, D ;

BELL, GI ;

BERELOWITZ, M ;

EPELBAUM, J ;

FENIUK, W ;

HUMPHREY, PPA ;

OCARROLL, AM ;

PATEL, YC ;

SCHONBRUNN, A ;

TAYLOR, JE ;

REISINE, T .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1995, 16 (03) :86-88

[6] Distribution of somatostatin receptor messenger RNAs in the rat gastrointestinal tract [J].

Krempels, K ;

Hunyady, B ;

OCarroll, AM ;

Mezey, E .

GASTROENTEROLOGY, 1997, 112 (06) :1948-1960

[7] ACTIVATION OF SOMATOSTATIN RECEPTOR SUBTYPE-2 INHIBITS ACID-SECRETION IN RATS [J].

LLOYD, KCK ;

WANG, J ;

AURANG, K ;

GRONHED, P ;

COY, DH ;

WALSH, JH .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1995, 268 (01) :G102-G106

[8] GASTRIC SOMATOSTATIN - A PARACRINE REGULATOR OF ACID-SECRETION [J].

MAKHLOUF, GM ;

SCHUBERT, ML .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1990, 39 (09) :138-142

[9] High basal gastric acid secretion in somatostatin receptor subtype 2 knockout mice [J].

Martinez, V ;

Curi, AP ;

Torkian, B ;

Schaeffer, JM ;

Wilkinson, HA ;

Walsh, JH ;

Tache, Y .

GASTROENTEROLOGY, 1998, 114 (06) :1125-1132

[10] DIFFERENTIAL KINETICS FOR IMMUNONEUTRALIZATION OF CIRCULATING GASTRIN BY GASTRIN MONOCLONAL-ANTIBODY AND ITS FAB(1) FRAGMENT IN RATS [J].

OHNING, GV ;

WONG, HC ;

WALSH, JH .

PEPTIDES, 1994, 15 (03) :417-423

← 1 2 →