New insights into the pathophysiology of the small airways in asthma

被引:40
作者
Tulic, MK
Hamid, Q
机构
[1] McGill Univ, Meakins Christie Labs, Montreal, PQ H2X 2P2, Canada
[2] Univ Western Australia, Telethon Inst Child Hlth Res, Div Cell Biol, Perth, WA 6009, Australia
[3] Univ Western Australia, Ctr Child Hlth Res, Perth, WA 6009, Australia
基金
加拿大健康研究院;
关键词
D O I
10.1016/j.ccm.2005.10.007
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Air-way inflammation and remodeling in asthma occur in the central airways and also in the small airways and in the lung parenchyma. The small airways and the lung parenchyma can produce many Th2 cytokines, chemokines, and mediators involved in initiation and perpetuation of the inflammatory process. The distal lung has been recognized as a predominant site of airflow obstruction in asthmatics. Distal inflammation has been described as more severe than large airway inflammation, and strong evidence of remodeling in the lung periphery is emerging. Recognition of asthma as a disease of the entire respiratory tract has clinical significance, highlighting the need to target the distal lung in any strategy for effective treatment of this disease.
引用
收藏
页码:41 / +
页数:13
相关论文
共 83 条
  • [1] Relationship of small airway chymase-positive mast cells and lung function in severe asthma
    Balzar, S
    Chu, HW
    Strand, M
    Wenzel, S
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2005, 171 (05) : 431 - 439
  • [2] INCREASES IN ACTIVATED T-LYMPHOCYTES, EOSINOPHILS, AND CYTOKINE MESSENGER-RNA EXPRESSION FOR INTERLEUKIN-5 AND GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN BRONCHIAL BIOPSIES AFTER ALLERGEN INHALATION CHALLENGE IN ATOPIC ASTHMATICS
    BENTLEY, AM
    MENG, Q
    ROBINSON, DS
    HAMID, Q
    KAY, AB
    DURHAM, SR
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1993, 8 (01) : 35 - 42
  • [3] EFFECT OF HIGH-DOSE INHALED FLUTICASONE PROPIONATE ON AIRWAY INFLAMMATION IN ASTHMA
    BOOTH, H
    RICHMOND, I
    WARD, C
    GARDINER, PV
    HARKAWAT, R
    WALTERS, EH
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1995, 152 (01) : 45 - 52
  • [4] Bronchial subepithelial fibrosis correlates with airway responsiveness to methacholine
    Boulet, LP
    Laviolette, M
    Turcotte, H
    Cartier, A
    Dugas, M
    Malo, JL
    Boutet, M
    [J]. CHEST, 1997, 112 (01) : 45 - 52
  • [5] PHYSIOLOGICAL EFFECTS OF EXPERIMENTAL AIRWAY OBSTRUCTION WITH BEADS
    BROWN, R
    WOOLCOCK, AJ
    VINCENT, NJ
    MACKLEM, PT
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1969, 27 (03) : 328 - +
  • [6] Efficacy response of inhaled beclomethasone dipropionate in asthma is proportional to dose and is improved by formulation with a new propellant
    Busse, WW
    Brazinsky, S
    Jacobson, K
    Stricker, W
    Schmitt, K
    Vanden Burgt, J
    Donnell, D
    Hannon, S
    Colice, GL
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 104 (06) : 1215 - 1222
  • [7] Airway structure and inflammatory cells in fatal attacks of asthma
    Carroll, N
    Carello, S
    Cooke, C
    James, A
    [J]. EUROPEAN RESPIRATORY JOURNAL, 1996, 9 (04) : 709 - 715
  • [8] The distribution of eosinophils and lymphocytes in the large and small airways of asthmatics
    Carroll, N
    Cooke, C
    James, A
    [J]. EUROPEAN RESPIRATORY JOURNAL, 1997, 10 (02) : 292 - 300
  • [9] Christodoulopoulos P, 2000, J ALLERGY CLIN IMMUN, V106, P479
  • [10] Cohen R, 1999, AM J RESP CRIT CARE, V159, pA631