Validation of different methods to compare isovolumic cardiac function in isolated hearts of varying sizes

被引:31
作者
Stromer, H
Cittadini, A
Szymanska, G
Apstein, CS
Morgan, JP
机构
[1] HARVARD UNIV, BETH ISRAEL HOSP,SCH MED,HARVARD THORNDIKE LAB, CARDIOVASC DIV,DEP MED, BOSTON, MA 02215 USA
[2] HARVARD UNIV, BETH ISRAEL HOSP,SCH MED,CHARLES A DANA RES INST, BOSTON, MA 02215 USA
[3] BOSTON UNIV, SCH MED, WHITAKER CARDIOVASC INST, CARDIAC MUSCLE RES LAB, BOSTON, MA 02118 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 1997年 / 272卷 / 01期
关键词
Langendorff heart; normalization for volume; left ventricular hypertrophy; cardiac growth;
D O I
10.1152/ajpheart.1997.272.1.H501
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Functional comparison of isolated hearts with different sizes has been difficult because function varies at different ventricular volumes. To date, no standard volume has been established. To determine the most accurate experimental approach, we tested five different methods to standardize volume in control hearts with different sizes but similar papillary muscle function and in hearts with concentric hypertrophy: intracardiac balloon volume (V-B) = 120 mu l (M1), V-B at diastolic pressure = 10 mmHg (M2) or diastolic wall stress = 4 kdyn/cm(2) (M3), V-B = 25 mu l/100 g body weight (M4), and V-B = 50% of volume at peak developed pressure (V-max; M5). Systolic and diastolic functions of control groups were different using M1 and comparable using M2 or M5. M3 and M4 showed borderline significant differences. We concluded that M5 and M2 were suitable to compare function among hearts of different sizes. If diastolic compliance is of interest, as in concentric hypertrophy, parameter-volume curves should be normalized by V-max to compare function at corresponding points of the Frank-Starling curve (e.g., at 50% of V-max, M5).
引用
收藏
页码:H501 / H510
页数:10
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