Adsorptive membranes for bilirubin removal

被引：69

作者：

Avramescu, ME ^{[1
]}

Sager, WFC ^{[1
]}

Borneman, Z ^{[1
]}

Wessling, M ^{[1
]}

机构：

[1] Univ Twente, Fac Chem Technol, Membrane Technol Grp, NL-7500 AE Enschede, Netherlands

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2004年 / 803卷 / 02期

关键词：

adsorptive membranes; bilirubin;

D O I：

10.1016/j.jchromb.2003.12.020

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we employed ethylene vinyl alcohol (EVAL) adsorptive membranes with bovine serum albumin (BSA) as bioligand for affinity supports for bilirubin (BR) retention. Microfiltration membranes were prepared from ternary or quaternary water/(1-octanol)/DMSO/EVAL systems. To obtain active binding sites for BSA, the EVAL membranes were either chemically functionalized in aqueous and organic medium and by plasma dischargement or physically activated by entrapping of active particles. Static BR removal was determined for all EVAL-BSA membranes. BR retentions relevant for human plasma were gained for the mixed adsorber membranes and additionally investigated in the dynamic mode. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：215 / 223

页数：9

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