Synthesis of 1-hydroxypyrazole glycine derivatives

被引：14

作者：

Calí, P ^{[1
]}

Begtrup, M ^{[1
]}

机构：

[1] Royal Danish Sch Pharm, Dept Med Chem, DK-2100 Copenhagen, Denmark

来源：

TETRAHEDRON | 2002年 / 58卷 / 08期

关键词：

arylglycine; amino acid; 1-hydroxypyrazole; imino malonate;

D O I：

10.1016/S0040-4020(02)00021-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel alpha-amino acids containing the 1-hydroxypyrazole ring has been prepared by addition of organomagnesium or organolithium intermediates to diethyl N-Boc-iminomalonate as an electrophilic glycine equivalent. Electrophiles, aryl and heteroaryl substituents were introduced in the pyrazole ring. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：1595 / 1605

页数：11

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