The effects of bupropion in vivo in the neostriatum of 5-day-old and adult rats

被引：9

作者：

Gazzara, RA ^{[1
]}

Andersen, SL ^{[1
]}

机构：

[1] SUNY BINGHAMTON,DEPT PSYCHOL,CTR DEV PSYCHOBIOL,BINGHAMTON,NY 13902

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1997年 / 100卷 / 01期

关键词：

dopamine; development/ontogeny; microdialysis; bupropion; dopamine reuptake; neostriatum;

D O I：

10.1016/S0165-3806(97)00006-0

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Infusion of six concentrations of the dopamine uptake inhibitor bupropion into the neostriatum increased extracellular dopamine in a dose-dependent manner in 5-day-old and adult rats. There was no age-related difference when calculated as a percentage of predrug dopamine baseline levels, but the absolute increase of dopamine was greater in the adult rats. Bupropion had only a minor effect on extracellular levels of DOPAC. (C) 1997 Elsevier Science B.V.

引用

页码：139 / 142

页数：4

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