Copper(I) bis(diphosphine) complexes as a basis for radiopharmaceuticals for positron emission tomography and targeted radiotherapy

被引:31
作者
Lewis, JS
Zweit, J
Dearling, JLJ
Rooney, BC
Blower, PJ
机构
[1] KENT & CANTERBURY HOSP,DEPT NUCL MED,CANTERBURY CT1 3NG,KENT,ENGLAND
[2] UNIV KENT,RES SCH BIOSCI,CANTERBURY CT2 7NJ,KENT,ENGLAND
[3] ROYAL MARSDEN HOSP,JOINT DEPT PHYS,SUTTON SM2 JPT,SURREY,ENGLAND
关键词
D O I
10.1039/cc9960001093
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Copper(I) bis(diphosphine) complexes provide an excellent basis for development of short/medium-lived PET (positron emission tomography) imaging and therapy agents containing copper radioisotopes, because of their extreme facility of synthesis and scope for derivatisation and bioconjugate formation.
引用
收藏
页码:1093 / 1094
页数:2
相关论文
共 15 条
[1]  
ANDERSON CJ, 1994, J NUCL MED, V35, pP161
[2]  
ANDERSON CJ, 1994, J NUCL MED, V35, pP106
[3]   SIMILAR LETHAL EFFECT IN MAMMALIAN-CELLS FOR 2 RADIOISOTOPES OF COPPER WITH DIFFERENT DECAY SCHEMES, CU-64 AND CU-67 [J].
APELGOT, S ;
COPPEY, J ;
GAUDEMER, A ;
GRISVARD, J ;
GUILLE, E ;
SASAKI, I ;
SISSOEFF, I .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1989, 55 (03) :365-384
[4]  
Berners-Price S.J., 1988, Struct. Bonding, V70, P27
[5]   COPPER(I) COMPLEXES WITH BIDENTATE TERTIARY PHOSPHINE-LIGANDS - SOLUTION CHEMISTRY AND ANTITUMOR-ACTIVITY [J].
BERNERSPRICE, SJ ;
JOHNSON, RK ;
MIRABELLI, CK ;
FAUCETTE, LF ;
MCCABE, FL ;
SADLER, PJ .
INORGANIC CHEMISTRY, 1987, 26 (20) :3383-3387
[6]  
BISCHOFDELALOYE A, 1994, J NUCL MED, V35, pP101
[7]  
BORMANS G, 1992, APPL RADIAT ISOTOPES, V12, P1437
[8]  
CARVALHO PA, 1992, J NUCL MED, V33, P1992
[9]  
FORD JM, 1990, PHARMACOL REV, V42, P15
[10]  
FUJIBAYASHI Y, 1991, Journal of Nuclear Medicine, V32, P974