Amyloids, prions and the inherent infectious nature of misfolded protein aggregates

被引：204

作者：

Soto, C ^{[1
]}

Estrada, L

Castilla, J

机构：

[1] Univ Texas, Med Branch, George & Cynthia Mitchell Ctr Alzheimers Dis & Re, Dept Neurol, Galveston, TX 77555 USA

[2] Univ Texas, Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA

[3] Univ Texas, Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2006年 / 31卷 / 03期

关键词：

D O I：

10.1016/j.tibs.2006.01.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Misfolded aggregates present in amyloid fibrils are associated with various diseases known as 'protein misfolding' disorders. Among them, prion diseases are unique in that the pathology can be transmitted by an infectious process involving an unprecedented agent known as a 'prion'. Prions are infectious proteins that can transmit biological information by propagating protein misfolding and aggregation. The molecular mechanism of prion conversion has a striking resemblance to the process of amyloid formation, suggesting that misfolded aggregates have an inherent ability to be transmissible. Intriguing recent data suggest that other protein misfolding disorders might also be transmitted by a prion-like infectious process.

引用

页码：150 / 155

页数：6

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