An efficient stereoselective synthesis of 1 alpha,24(R)-dihydroxyvitamin D-3 by the dienyne route.

被引：22

作者：

Fall, Y

Torneiro, M

Castedo, L

Mourino, A

机构：

[1] CSIC,DEPT QUIM ORGAN,SANTIAGO COMPOSTE 15706,SPAIN

[2] CSIC,SECC ALCALOIDES,SANTIAGO COMPOSTE 15706,SPAIN

来源：

TETRAHEDRON | 1997年 / 53卷 / 13期

关键词：

D O I：

10.1016/S0040-4020(97)00139-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1 alpha,24(R)-Dihydroxyvitamin D-3 (5e) was synthesized. The key step in the preparation of the side-chain was opening of the chiral epoxide 10 by the alpha-anion of the nitrile 9, The triene system was synthesized by the dienyne route. (C) 1997 Elsevier Science Ltd.

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页码：4703 / 4714

页数：12

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