High frequency of carbapenem-resistant Acinetobacter baumannii in patients with diabetes mellitus in Saudi Arabia

被引：38

作者：

Alsultan, A. A. ^{[1
]}

Evans, B. A. ^{[2
]}

Elsayed, E. A. ^{[1
]}

Al-Thawadi, S. I. ^{[3
]}

Al-Taher, A. Y. ^{[1
]}

Amyes, S. G. B. ^{[4
]}

Al-Dughaym, A. M. ^{[1
]}

Hamouda, A. ^{[5
]}

机构：

[1] King Faisal Univ, Coll Med, Alahsa 31982, Saudi Arabia

[2] Anglia Ruskin Univ, Dept Life Sci, Fac Sci & Technol, Cambridge CB1 1PT, England

[3] King Faisal Specialist Hosp & Res Ctr, Riyadh 11211, Saudi Arabia

[4] Univ Edinburgh, Med Microbiol, Edinburgh EH16 45B, Midlothian, Scotland

[5] Taibah Univ, Dept Clin Biochem, Almadinah, Almunawarah, Saudi Arabia

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 2013年 / 62卷

关键词：

MULTIPLEX PCR; GENES; PREVALENCE; EXPRESSION; DIVERSITY; STRAINS;

D O I：

10.1099/jmm.0.057216-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Carbapenem-resistant Acinetobacter baumannii is becoming increasingly prevalent in patients with diabetes mellitus in the Middle East. We examined the relationship of these bacteria and their resistance mechanisms to the diabetic disease status of patients in Saudi Arabia. Susceptibilities of 271 isolates to carbapenems, tigecycline and colistin were determined, followed by detection of carbapenemase genes. A bla(VIM) gene was detected in similar to 95 % of isolates; bla(OXA-23) and bla(OXA-40) genes were also prevalent. Diabetic patients were significantly more likely to carry carbapenem-resistant isolates. Carbapenem-resistant A. baumannii is a serious problem in diabetic patients, and molecular detection of resistance mechanisms in these isolates is required.

引用

页码：885 / 888

页数：4

共 20 条

[1]

Prevalence of antimicrobial resistance among gram-negative isolates in an adult intensive care unit at a tertiary care center in Saudi Arabia [J].