In Vitro Susceptibility Testing of Bedaquiline against Mycobacterium avium Complex

被引：45

作者：

Brown-Elliott, Barbara A. ^{[1
]}

Philley, Julie V. ^{[2
]}

Griffith, David E. ^{[2
]}

Thakkar, Foram ^{[2
]}

Wallace, Richard J., Jr. ^{[1
,2
]}

机构：

[1] Univ Texas Hlth Sci Ctr Tyler, Mycobacteria Nocardia Res Lab, Dept Microbiol, Tyler, TX 75708 USA

[2] Univ Texas Hlth Sci Ctr Tyler, Dept Med, Tyler, TX USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 02期

关键词：

Mycobacterium avium complex; bedaquiline; nontuberculous mycobacteria; susceptibility testing; MULTIDRUG-RESISTANT TUBERCULOSIS; ATP SYNTHASE; DIARYLQUINOLINE TMC207; CROSS-RESISTANCE; LUNG-DISEASE; DRUG; RIFAPENTINE; CLOFAZIMINE; THERAPY;

D O I：

10.1128/AAC.01798-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

We performed bedaquiline broth microdilution susceptibility testing using Clinical and Laboratory Standards Institute (CLSI) guidelines on 103 respiratory isolates of Mycobacterium avium complex (MAC), including multidrug-resistant isolates. Approximately 90% of isolates had bedaquiline MICs of <= 0.008 mu g/ml, and 102/103 isolates had MICs of <= 0.015 mu g/ml. Bedaquiline has excellent potential for use in patients with MAC infections, although for reasons of its metabolism by the cytochrome P450 system, it should not be given with rifampin.

引用

页数：4

共 17 条

[1]

A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis [J].

Andries, K ;

Verhasselt, P ;

Guillemont, J ;

Göhlmann, HWH ;

Neefs, JM ;

Winkler, H ;

Van Gestel, J ;

Timmerman, P ;

Zhu, M ;

Lee, E ;

Williams, P ;

de Chaffoy, D ;

Huitric, E ;

Hoffner, S ;

Cambau, E ;

Truffot-Pernot, C ;

Lounis, N ;

Jarlier, V .

SCIENCE, 2005, 307 (5707) :223-227

[2]

Clinical and Laboratory Standards Institute, 2011, SUSCEPTIBILITY TESTI

[3]

FDA Approval of Bedaquiline - The Benefit-Risk Balance for Drug-Resistant Tuberculosis [J].

Cox, Edward ;

Laessig, Katherine .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (08) :689-691

[4]

Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline [J].

Diacon, Andreas H. ;

Pym, Alexander ;

Grobusch, Martin P. ;

de los Rios, Jorge M. ;

Gotuzzo, Eduardo ;

Vasilyeva, Irina ;

Leimane, Vaira ;

Andries, Koen ;

Bakare, Nyasha ;

De Marez, Tine ;

Haxaire-Theeuwes, Myriam ;

Lounis, Nacer ;

Meyvisch, Paul ;

De Paepe, Els ;

van Heeswijk, Rolf P. G. ;

Dannemann, Brian .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (08) :723-732

[5]

The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis [J].

Diacon, Andreas H. ;

Pym, Alexander ;

Grobusch, Martin ;

Patientia, Ramonde ;

Rustomjee, Roxana ;

Page-Shipp, Liesl ;

Pistorius, Christoffel ;

Krause, Rene ;

Bogoshi, Mampedi ;

Churchyard, Gavin ;

Venter, Amour ;

Allen, Jenny ;

Palomino, Juan Carlos ;

De Marez, Tine ;

van Heeswijk, Rolf P. G. ;

Lounis, Nacer ;

Meyvisch, Paul ;

Verbeeck, Johan ;

Parys, Wim ;

de Beule, Karel ;

Andries, Koen ;

Mc Neeley, David F. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (23) :2397-2405

[6]

Compassionate Use of Bedaquiline for the Treatment of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis: Interim Analysis of a French Cohort [J].

Guglielmetti, Lorenzo ;

Le Du, Damien ;

Jachym, Mathilde ;

Henry, Benoit ;

Martin, Diane ;

Caumes, Eric ;

Veziris, Nicolas ;

Metivier, Nathalie ;

Robert, Jerome .

CLINICAL INFECTIOUS DISEASES, 2015, 60 (02) :188-194

[7]

Cross-Resistance between Clofazimine and Bedaquiline through Upregulation of MmpL5 in Mycobacterium tuberculosis [J].

Hartkoorn, Ruben C. ;

Uplekar, Swapna ;

Cole, Stewart T. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (05) :2979-2981

[8]

In vitro antimycobacterial spectrum of a diarylquinoline ATP synthase inhibitor [J].

Huitric, Emma ;

Verhasselt, Peter ;

Andries, Koen ;

Hoffner, Sven E. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (11) :4202-4204

[9]

ATP Synthase Inhibition of Mycobacterium avium Is Not Bactericidal [J].

Lounis, Nacer ;

Gevers, Tom ;

Van den Berg, Joke ;

Vranckx, Luc ;

Andries, Koen .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (11) :4927-4929

[10]

Mahajan Rajiv, 2013, Int J Appl Basic Med Res, V3, P1, DOI 10.4103/2229-516X.112228

← 1 2 →