Recent insights into humoral and cellular immune responses against malaria

被引：93

作者：

Beeson, James G. ^{[1
]}

Osier, Faith H. A. ^{[2
]}

Engwerda, Christian R. ^{[3
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia

[2] Kenya Govt Med Res Ctr, Ctr Geog Med Res, Kilifi, Kenya

[3] Royal Brisbane Hosp, Bancroft Ctr, Queensland Inst Med Res, Brisbane, Qld 4029, Australia

来源：

TRENDS IN PARASITOLOGY | 2008年 / 24卷 / 12期

关键词：

D O I：

10.1016/j.pt.2008.08.008

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Effective immunity to malaria has been clearly demonstrated among individuals naturally exposed to malaria, and can be induced by experimental infections in animals and humans. The large number of malaria antigens has presented a major challenge to identifying protective responses and their targets, and it is likely that robust immunity is mediated by responses to multiple antigens. These include merozoite surface antigens and invasion ligands, variant antigens on the surface of parasitized red blood cells, in addition to sporozoite and liver-stage antigens. Immunity seems to require humoral and cellular immune components, probably in co-operation, although the relative importance of each remains unclear. This review summarizes recent progress towards understanding the targets and mechanisms that are important for mediating immunity to malaria.

引用

页码：578 / 584

页数：7

共 75 条

[1] Achtman AH, 2005, CURR TOP MICROBIOL, V297, P71
[2] A FAMILY OF ERYTHROCYTE BINDING-PROTEINS OF MALARIA PARASITES
ADAMS, JH
SIM, BKL
DOLAN, SA
FANG, XD
KASLOW, DC
MILLER, LH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (15) : 7085 - 7089
[3] A role for natural regulatory T cells in the pathogenesis of experimental cerebral malaria
Amante, Fiona H.
Stanley, Amanda C.
Randall, Louise M.
Zhou, Yonghong
Haque, Ashraful
McSweeney, Karli
Waters, Andrew P.
Janse, Chris J.
Good, Michael F.
Hill, Geoff R.
Engwerda, Christian R.
[J]. AMERICAN JOURNAL OF PATHOLOGY, 2007, 171 (02) : 548 - 559
[4] Quantitative imaging of Plasmodium transmission from mosquito to mammal
Amino, R
Thiberge, S
Martin, B
Celli, S
Shorte, S
Frischknecht, F
Ménard, R
[J]. NATURE MEDICINE, 2006, 12 (02) : 220 - 224
[5] Structural insight into Epitopes in the pregnancy-associated malaria protein VAR2CSA
Andersen, Pernille
Nielsen, Morten A.
Resende, Mafalda
Rask, Thomas S.
Dahlback, Madeleine
Theander, Thor
Lund, Ole
Salanti, Ali
[J]. PLOS PATHOGENS, 2008, 4 (02)
[6] Evidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSA
Avril, Marion
Kulasekara, Bridget R.
Gose, Severin O.
Rowe, Chris
Dahlback, Madeleine
Duffy, Patrick E.
Fried, Michal
Salanti, Ali
Misher, Lynda
Narum, David L.
Smith, Joseph D.
[J]. INFECTION AND IMMUNITY, 2008, 76 (04) : 1791 - 1800
[7] Pathogenesis of Plasmodium falciparum malaria:: the roles of parasite adhesion and antigenic variation
Beeson, JG
Brown, GV
[J]. CELLULAR AND MOLECULAR LIFE SCIENCES, 2002, 59 (02) : 258 - 271
[8] Antigenic differences and conservation among placental Plasmodium falciparum-infected erythrocytes and acquisition of variant-specific and cross-reactive antibodies
Beeson, JG
Mann, EJ
Byrne, TJ
Caragounis, A
Elliott, SR
Brown, GV
Rogerson, SJ
[J]. JOURNAL OF INFECTIOUS DISEASES, 2006, 193 (05) : 721 - 730
[9] ANTIGENIC VARIATION IN PLASMODIUM-FALCIPARUM
BIGGS, BA
GOOZE, L
WYCHERLEY, K
WOLLISH, W
SOUTHWELL, B
LEECH, JH
BROWN, GV
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (20) : 9171 - 9174
[10] ANTIBODIES THAT PROTECT HUMANS AGAINST PLASMODIUM-FALCIPARUM BLOOD STAGES DO NOT ON THEIR OWN INHIBIT PARASITE GROWTH AND INVASION INVITRO, BUT ACT IN COOPERATION WITH MONOCYTES
BOUHAROUNTAYOUN, H
ATTANATH, P
SABCHAREON, A
CHONGSUPHAJAISIDDHI, T
DRUILHE, P
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (06) : 1633 - 1641

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