Clustered protocadherins

被引：136

作者：

Chen, Weisheng V. ^{[1
]}

Maniatis, Tom ^{[1
]}

机构：

[1] Columbia Univ, Med Ctr, Dept Biochem & Mol Biophys, New York, NY 10032 USA

来源：

DEVELOPMENT | 2013年 / 140卷 / 16期

基金：

美国国家卫生研究院;

关键词：

CTCF; Cohesin; Promoter choice; Single cell diversity; Homophilic interaction; Self-avoidance; GAMMA-PROTOCADHERINS; COMBINATORIAL EXPRESSION; HOMOPHILIC INTERACTION; REGULATORY ELEMENTS; GENE-REGULATION; SELF-AVOIDANCE; ALPHA FAMILY; CELL; DIVERSITY; IDENTIFICATION;

D O I：

10.1242/dev.090621

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The majority of vertebrate protocadherin (Pcdh) genes are clustered in a single genomic locus, and this remarkable genomic organization is highly conserved from teleosts to humans. These clustered Pcdhs are differentially expressed in individual neurons, they engage in homophilic trans-interactions as multimers and they are required for diverse neurodevelopmental processes, including neurite self-avoidance. Here, we provide a concise overview of the molecular and cellular biology of clustered Pcdhs, highlighting how they generate single cell diversity in the vertebrate nervous system and how such diversity may be used in neural circuit assembly.

引用

页码：3297 / 3302

页数：6

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