Life of a clathrin coat: insights from clathrin and AP structures

被引:169
作者
Edeling, MA
Smith, C [1 ]
Owen, D
机构
[1] Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England
[2] Univ Cambridge, Dept Clin Biochem, Cambridge Inst Med Res, Cambridge CB2 2XY, England
关键词
D O I
10.1038/nrm1786
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Membrane sorting between secretory and endocytic organelles is predominantly controlled by small carrier vesicles or tubules that have specific protein coats on their cytoplasmic surfaces. Clathrin-clathrin-adaptor coats function in many steps of intracellular transport and are the most extensively studied of all transport-vesicle coats. In recent years, the determination of structures of clathrin assemblies by electron microscopy, of domains of clathrin and of its adaptors has improved our understanding of the molecular mechanisms of clathrin-coated-vesicle assembly and disassembly.
引用
收藏
页码:32 / 44
页数:13
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