A road map for efficient and reliable human genome epidemiology

被引：161

作者：

Ioannidis, JPA ^{[1
]}

Gwinn, M

Little, J

Higgins, JPT

Bernstein, JL

Boffetta, P

Bondy, M

Bray, MS

Brenchley, PE

Buffler, PA

Casas, JP

Chokkalingam, A

Danesh, J

Smith, GD

Dolan, S

Duncan, R

Gruis, NA

Hartge, P

Hashibe, M

Hunter, DJ

Jarvelin, MR

Malmer, B

Maraganore, DM

Newton-Bishop, JA

O'Brien, TR

Petersen, G

Riboli, E

Salanti, G

Seminara, D

Smeeth, L

Taioli, E

Timpson, N

Uitterlinden, AG

Vineis, P

Wareham, N

Winn, DM

Zimmern, R

Khoury, MJ

机构：

[1] Univ Ioannina, Sch Med, Dept Hyg & Epidemiol, Clin & Mol Epidemiol Unit, GR-45110 Ioannina, Greece

[2] Fdn Res & Technol Hellas, Biomed Res Inst, GR-45110 Ioannina, Greece

[3] Tufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA

[4] Ctr Dis Control & Prevent, Off Genom & Dis Prevent, Atlanta, GA 30333 USA

[5] Univ Ottawa, Dept Epidemiol & Community Med, Ottawa, ON K1H 8M5, Canada

[6] Univ Cambridge, MRC, Biostat Unit, Cambridge CB2 2SR, England

[7] Strangeways Res Lab, Publ Hlth Genet Unit, Cambridge CB1 8RN, England

[8] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA

[9] Int Agcy Res Canc, F-69008 Lyon, France

[10] Univ Texas, MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA

[11] Baylor Coll Med, USDA ARS, Childrens Nutr Res Ctr, Houston, TX 77030 USA

[12] Royal Infirm, Manchester Inst Nephrol & Transplantat, Renal Res Labs, Manchester M13 9WL, Lancs, England

[13] Univ Calif Berkeley, Berkeley, CA 94720 USA

[14] Univ London London Sch Hyg & Trop Med, Dept Epidemiol & Populat Hlth, London WC1E 7HT, England

[15] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB1 8RN, England

[16] Univ Bristol, Dept Social Med, Bristol BS8 2PR, Avon, England

[17] March Dimes, White Plains, NY 10605 USA

[18] WHO, CH-1211 Geneva, Switzerland

[19] Leiden Univ Med Ctr, Dept Dermatol, NL-2333 AL Leiden, Netherlands

[20] NCI, Div Canc Epidemiol & Genet, Rockville, MD 20852 USA

[21] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

[22] Univ London Imperial Coll Sci & Technol, Dept Epidemiol & Publ Hlth, London W2 1PG, England

[23] Univ Oulu, Dept Publ Hlth Sci & Gen Practice, Oulu, Finland

[24] Umea Univ Hosp, Dept Radiat Sci, Umea, Sweden

[25] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

[26] CR UK Clin Ctr, Genet Epidemiol Div, Leeds LS8 7FT, W Yorkshire, England

[27] Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA

[28] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA

[29] Univ Pittsburgh, Med Ctr, Pittsburgh, PA 15232 USA

[30] Erasmus MC, Dept Internal Med, NL-3000 DR Rotterdam, Netherlands

[31] Erasmus MC, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands

[32] Inst Sci Interchange Fdn, Turin, Italy

[33] MRC, Epidemiol Unit, Elsie Widdowson Labs, Cambridge CB1 9NL, England

来源：

NATURE GENETICS | 2006年 / 38卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/ng0106-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Networks of investigators have begun sharing best practices, tools and methods for analysis of associations between genetic variation and common diseases. A Network of Investigator Networks has been set up to drive the process, sponsored by the Human Genome Epidemiology Network. A workshop is planned to develop consensus guidelines for reporting results of genetic association studies. Published literature databases will be integrated, and unpublished data, including 'negative' studies, will be captured by online journals and through investigator networks. Systematic reviews will be expanded to include more meta-analyses of individual-level data and prospective meta-analyses. Field synopses will offer regularly updated overviews.

引用

页码：3 / 5

页数：3

共 24 条

[1] The revised CONSORT statement for reporting randomized trials: Explanation and elaboration [J].