Focal segmental glomerulosclerosis with acute renal failure associated with alpha-interferon therapy

被引:55
作者
Coroneos, E
Petrusevska, G
Varghese, F
Truong, LD
机构
[1] BAYLOR COLL MED,DEPT MED,HOUSTON,TX 77030
[2] BAYLOR COLL MED,RENAL PATHOL LAB,HOUSTON,TX 77030
[3] DIAGNOST CLIN HOUSTON,DEPT MED,HOUSTON,TX
关键词
alpha-interferon; focal segmental glomerulosclerosis; tubulointerstitial nephritis; nephrotic syndrome; acute reraal failure;
D O I
10.1016/S0272-6386(96)90389-3
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Both alpha- and beta- interferons (IFNs) have been increasingly used far the treatment of many types of malignancy, and recently the use of alpha-IFN in the management of hepatitis C virus (HCV)( infection with or without renal involvement has been emphasized, We report a patient who developed nephrotic syndrome and acute renal failure while being treated with alpha-IFN for HCV infection, The renal biopsy showed focal segmental glomerulosclerosis and tubulointerstitial nephritis, Although several renal lesions have been described in association with either alpha-IFN treatment or HCV infection, focal segmental glomerulosclerosis has not been emphasized in either instance, This case also indicates that when renal abnormalities occur during treatment of HCV infection with alpha-)FN, kidney biopsy may define the responsible renal lesions, suggest possible association with other conditions, and serve as a guideline for proper management. (C) 1996 by the National Kidney Foundation, Inc.
引用
收藏
页码:888 / 892
页数:5
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