Clip compression injury in the spinal cord: A correlative study of neurological and morphological alterations

被引:54
作者
vonEuler, M
Seiger, A
Sundstrom, E
机构
[1] Dept. Clin. Neurosci. and Fam. Med., Division of Geriatric Medicine, Huddinge University Hospital
关键词
D O I
10.1006/exnr.1997.6481
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Rats subjected to experimental spinal cord compression of different degrees induced by aneurysm clips were neurologically tested 3 and 5 weeks postinjury. The development of spinal cord tissue destruction over time was similar to what has been described for other experimental spinal cord injuries with characteristics such as early edema, axonal swelling, and later necrosis. Three weeks after injury a reactive gliosis was found at the injury epicenter and regenerating axons could be identified in the otherwise necrotic cavity. The extent of degeneration was highly correlated with the closing force of the aneurysm clip. The results of a number of neurological tests were correlated to the degree of clip-induced compression, to lesion volume, and to the remaining area of white matter at the epicenter. The neurological tests with the highest correlation to morphological descriptors were beam walk (r(s) = 0.89-0.95) and motor performance score (r(s) = 0.88-0.92). We conclude that the motor performance score, previously validated for photochemically induced ischemic spinal cord injuries, is equally suitable for clip compression injuries as a fast and reliable neurological test paradigm. (C) 1997 Academic Press.
引用
收藏
页码:502 / 510
页数:9
相关论文
共 37 条
[1]  
Allen A., 1911, J AM MED ASS, V57, P878, DOI 10.1001/jama.1911.04260090100008
[2]  
BALENTINE JD, 1978, LAB INVEST, V39, P236
[3]   A SENSITIVE AND RELIABLE LOCOMOTOR RATING-SCALE FOR OPEN-FIELD TESTING IN RATS [J].
BASSO, DM ;
BEATTIE, MS ;
BRESNAHAN, JC .
JOURNAL OF NEUROTRAUMA, 1995, 12 (01) :1-21
[4]   SPINAL-CORD INJURY PRODUCED BY CONSISTENT MECHANICAL DISPLACEMENT OF THE CORD IN RATS - BEHAVIORAL AND HISTOLOGIC ANALYSIS [J].
BEHRMANN, DL ;
BRESNAHAN, JC ;
BEATTIE, MS ;
SHAH, BR .
JOURNAL OF NEUROTRAUMA, 1992, 9 (03) :197-217
[5]   A RANDOMIZED, CONTROLLED TRIAL OF METHYLPREDNISOLONE OR NALOXONE IN THE TREATMENT OF ACUTE SPINAL-CORD INJURY - RESULTS OF THE 2ND NATIONAL ACUTE SPINAL-CORD INJURY STUDY [J].
BRACKEN, MB ;
SHEPARD, MJ ;
COLLINS, WF ;
HOLFORD, TR ;
YOUNG, W ;
BASKIN, DS ;
EISENBERG, HM ;
FLAMM, E ;
LEOSUMMERS, L ;
MAROON, J ;
MARSHALL, LF ;
PEROT, PL ;
PIEPMEIER, J ;
SONNTAG, VKH ;
WAGNER, FC ;
WILBERGER, JE ;
WINN, HR .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (20) :1405-1411
[6]   A BEHAVIORAL AND ANATOMICAL ANALYSIS OF SPINAL-CORD INJURY PRODUCED BY A FEEDBACK-CONTROLLED IMPACTION DEVICE [J].
BRESNAHAN, JC ;
BEATTIE, MS ;
TODD, FD ;
NOYES, DH .
EXPERIMENTAL NEUROLOGY, 1987, 95 (03) :548-570
[7]   CHARACTERIZATION OF PHOTOCHEMICALLY INDUCED SPINAL-CORD INJURY IN THE RAT BY LIGHT AND ELECTRON-MICROSCOPY [J].
BUNGE, MB ;
HOLETS, VR ;
BATES, ML ;
CLARKE, TS ;
WATSON, BD .
EXPERIMENTAL NEUROLOGY, 1994, 127 (01) :76-93
[8]   AXONAL ELONGATION INTO PERIPHERAL NERVOUS-SYSTEM BRIDGES AFTER CENTRAL NERVOUS-SYSTEM INJURY IN ADULT-RATS [J].
DAVID, S ;
AGUAYO, AJ .
SCIENCE, 1981, 214 (4523) :931-933
[9]  
Dohrmann G J, 1976, Surg Neurol, V5, P315
[10]   THE VALUE OF DECOMPRESSION FOR ACUTE EXPERIMENTAL SPINAL-CORD COMPRESSION INJURY [J].
DOLAN, EJ ;
TATOR, CH ;
ENDRENYI, L .
JOURNAL OF NEUROSURGERY, 1980, 53 (06) :749-755