Erythrocytes: Oxygen Sensors and Modulators of Vascular Tone

被引：220

作者：

Ellsworth, Mary L. ^{[1
]}

Ellis, Christopher G. ^{[2
]}

Goldman, Daniel ^{[2
]}

Stephenson, Alan H. ^{[1
]}

Dietrich, Hans H. ^{[3
]}

Sprague, Randy S. ^{[1
]}

机构：

[1] St Louis Univ, Sch Med, Dept Pharmacol & Physiol Sci, St Louis, MO 63104 USA

[2] Univ Western Ontario, Dept Med Biophys, London, ON, Canada

[3] St Louis Univ, Sch Med, Dept Neurol Surg, St Louis, MO 63104 USA

来源：

PHYSIOLOGY | 2009年 / 24卷 / 02期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

RED-BLOOD-CELL; SIGNAL-TRANSDUCTION PATHWAY; G-PROTEIN; ATP RELEASE; SKELETAL-MUSCLE; SMOOTH-MUSCLE; NITRIC-OXIDE; ADENOSINE-TRIPHOSPHATE; S-NITROSOHEMOGLOBIN; ADENYLYL-CYCLASE;

D O I：

10.1152/physiol.00038.2008

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Through oxygen-dependent release of the vasodilator ATP, the mobile erythrocyte plays a fundamental role in matching microvascular oxygen supply with local tissue oxygen demand. Signal transduction within the erythrocyte and microvessels as well as feedback mechanisms controlling ATP release have been described. Our understanding of the impact of this novel control mechanism will rely on the integration of in vivo experiments and computational models.

引用

页码：107 / 116

页数：10

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