Substance P immunoreactive nerves and interstitial cells of Cajal in the rat and guinea-pig ileum. A histochemical and quantitative study

被引：24

作者：

Vannucchi, MG ^{[1
]}

Corsani, L ^{[1
]}

Faussone-Pellegrini, MS ^{[1
]}

机构：

[1] Univ Florence, Dept Anat Histol & Forens Med, Sect Histol E Aliara, Florence, Italy

来源：

NEUROSCIENCE LETTERS | 1999年 / 268卷 / 01期

关键词：

enteric plexuses; guinea-pig; ileum; interstitial cells of cajal; neurokinin receptors; rat; substance p;

D O I：

10.1016/S0304-3940(99)00366-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The substance P (SP)-containing nerves at the deep (DMP) and myenteric (MP) plexuses and the related interstitial cells of Cajal (ICC-DMP and ICC-MP) were immunohistochemically studied in rat and guinea-pig ileum. All the ICC expressed SP-preferred receptor NK1r: the ICC-DMP showed an intense and the ICC-MP a faint NK1r-immunoreactivity(lR). c-kit-labeling confirmed that they were ICC. The SP-IR nerves at the DMP were significantly more numerous in the guinea-pig than in the rat, and more numerous than those at the MP in both animal species. All the ICC-DMP in the guinea-pig and half of them in the rat were close to SP-IR nerves. The ICC-MP were rarely near to SP-IR nerves in either species. The SP-innervation shows interspecies differences at the DMP that imply a different tachykinergic control of the local ICC. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：49 / 52

页数：4

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