Quantitation of organophosphorus nerve agent metabolites in human urine using isotope dilution gas chromatography tandem mass spectrometry

被引：59

作者：

Driskell, WJ

Shih, M

Needham, LL

Barr, DB

机构：

[1] USA, Med Res Inst Chem Def, Aberdeen Proving Ground, MD 21010 USA

[2] CDC, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA

来源：

JOURNAL OF ANALYTICAL TOXICOLOGY | 2002年 / 26卷 / 01期

关键词：

D O I：

10.1093/jat/26.1.6

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An isotope dilution gas chromatography-tandem mass spectrometric (GC-MS-MS) method was developed for quantitating the urinary metabolites of the organophosphorus nerve agents sarin, soman, tabun (GA), VX, and GF. Urine samples were concentrated by codistillation with acetonitrile, derivatized by methylation with diazomethane, and analyzed by GC-MS-MS. The limits of detection were less than 4 μg/L for all the analytes except for the GA metabolite, which had a limit of detection of less than 20 μg/L.

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页码：6 / 10

页数：5

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