Plasma concentrations of the antioxidants β-carotene and α-tocopherol in relation to lung function

被引:31
作者
Grievink, L
Smit, HA
van't Veer, P
Brunekreef, B
Kromhout, D
机构
[1] RIVM, Natl Inst Publ Hlth & Environm, Dept Chron Dis Epidemiol, Bilthoven, Netherlands
[2] Agr Univ Wageningen, Environm & Occupat Hlth Grp, NL-6700 HB Wageningen, Netherlands
[3] Agr Univ Wageningen, Div Human Nutr & Epidemiol, NL-6700 HB Wageningen, Netherlands
关键词
plasma antioxidants; lung function; epidemiology;
D O I
10.1038/sj.ejcn.1600854
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Objective: To study the association between plasma antioxidants (beta-carotene and alpha-tocopherol) and lung function in Dutch adults aged 20-59 y. Design: Cross-sectional. Setting: Population-based study. Subjects: A random sample (n=367) was drawn from all participants (men and women) aged 20-59 y with reproducible lung function measurements in 1995. Intervention: Completion of general questionnaire and physical examination. Main outcome measurements: Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and plasma levels of beta-carotene and alpha-tocopherol. Results: Subjects with a high plasma beta-carotene level (90th percentile, that is .57 mu mol/L) tended to have a higher FEV1 (73 mi, s.e.m. 60 mi; P = 0.22) and a higher FVC (147 mi, s.e.m. 76 mi, P = 0.05) than subjects with a low plasma beta-carotene level(10th percentile, that is 0.11 mu mol/L) after adjustment for age, height, gender, smoking status, pack-years of smoking and alcohol consumption. There was no difference in lung function between subjects with high and low plasma alpha-tocopherol concentrations. Conclusions: The results suggest that subjects with a high plasma beta-carotene tended to have a higher FVC than subjects with a low plasma beta-carotene concentration which was borderline statistically significant. The difference for FEV1 between high and low levels of plasma beta-carotene tended to be in the same positive direction as that of FVC but did not reach the pre-set statistical significance lever. There is no relation between plasma alpha-tocopherol and lung function.
引用
收藏
页码:813 / 817
页数:5
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