Herpes simplex virus: receptors and ligands for cell entry

被引:432
作者
Spear, PG [1 ]
机构
[1] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA
关键词
D O I
10.1111/j.1462-5822.2004.00389.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Entry of herpes simplex virus (HSV) into cells depends upon multiple cell surface receptors and multiple proteins on the surface of the virion. The cell surface receptors include heparan sulphate chains on cell surface proteoglycans, a member of the tumor necrosis factor (TNF) receptor family and two members of the immunoglobulin superfamily related to the poliovirus receptor. The HSV ligands for these receptors are the envelope glycoproteins gB and gC for heparan sulphate and gD for the protein receptors and specific sites in heparan sulphate generated by certain 3-O-sulfotransferases. HSV gC also binds to the C3b component of complement and can block complement-mediated neutralization of virus. The purposes of this review are to summarize available information about these cell surface receptors and the viral ligands, gC and gD, and to discuss roles of these viral glycoproteins in immune evasion and cellular responses as well as in viral entry.
引用
收藏
页码:401 / 410
页数:10
相关论文
共 77 条
  • [1] SEQUENTIAL ISOLATION OF PROTEOGLYCAN SYNTHESIS MUTANTS BY USING HERPES-SIMPLEX VIRUS AS A SELECTIVE AGENT - EVIDENCE FOR A PROTEOGLYCAN-INDEPENDENT VIRUS ENTRY PATHWAY
    BANFIELD, BW
    LEDUC, Y
    ESFORD, L
    SCHUBERT, K
    TUFARO, F
    [J]. JOURNAL OF VIROLOGY, 1995, 69 (06) : 3290 - 3298
  • [2] Defects in nuclear and cytoskeletal morphology and mitochondrial localization in spermatozoa of mice lacking nectin-2, a component of cell-cell adherens junctions
    Bouchard, MJ
    Dong, YZ
    McDermott, BM
    Lam, DH
    Brown, KR
    Shelanski, M
    Bellvé, AR
    Racaniello, VR
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (08) : 2865 - 2873
  • [3] Herpes simplex virus glycoprotein D bound to the human receptor HveA
    Carfí, A
    Willis, SH
    Whitbeck, JC
    Krummenacher, C
    Cohen, GH
    Eisenberg, RJ
    Wiley, DC
    [J]. MOLECULAR CELL, 2001, 8 (01) : 169 - 179
  • [4] Glycoprotein B plays a predominant role in mediating herpes simplex virus type 2 attachment and is required for entry and cell-to-cell spread
    Cheshenko, N
    Herold, BC
    [J]. JOURNAL OF GENERAL VIROLOGY, 2002, 83 : 2247 - 2255
  • [5] IDENTIFICATION OF FUNCTIONAL REGIONS OF HERPES-SIMPLEX VIRUS GLYCOPROTEIN GO BY USING LINKER-INSERTION MUTAGENESIS
    CHIANG, HY
    COHEN, GH
    EISENBERG, RJ
    [J]. JOURNAL OF VIROLOGY, 1994, 68 (04) : 2529 - 2543
  • [6] The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cells
    Cocchi, F
    Menotti, L
    Mirandola, P
    Lopez, M
    Campadelli-Fiume, G
    [J]. JOURNAL OF VIROLOGY, 1998, 72 (12) : 9992 - 10002
  • [7] Structure-based mutagenesis of herpes simplex virus glycoprotein D defines three critical regions at the gD-HveA/HVEM binding interface
    Connolly, SA
    Landsburg, DJ
    Carfi, A
    Wiley, DC
    Cohen, GH
    Eisenberg, RJ
    [J]. JOURNAL OF VIROLOGY, 2003, 77 (14) : 8127 - 8140
  • [8] Structure-based analysis of the herpes simplex virus glycoprotein D binding site present on herpesvirus entry mediator HveA (HVEM)
    Connolly, SA
    Landsburg, DJ
    Carfi, A
    Wiley, DC
    Eisenberg, RJ
    Cohen, GH
    [J]. JOURNAL OF VIROLOGY, 2002, 76 (21) : 10894 - 10904
  • [9] Co-stimulatory members of the TNFR family: Keys to effective T-cell immunity?
    Croft, M
    [J]. NATURE REVIEWS IMMUNOLOGY, 2003, 3 (08) : 609 - 620
  • [10] THE HUMAN PRR2 GENE, RELATED TO THE HUMAN POLIOVIRUS RECEPTOR GENE (PVR), IS THE TRUE HOMOLOG OF THE MURINE MPH GENE
    EBERLE, F
    DUBREUIL, P
    MATTEI, MG
    DEVILARD, E
    LOPEZ, M
    [J]. GENE, 1995, 159 (02) : 267 - 272