Amnesic shellfish poison

被引：137

作者：

Jeffery, B ^{[1
]}

Barlow, T ^{[1
]}

Moizer, K ^{[1
]}

Paul, S ^{[1
]}

Boyle, C ^{[1
]}

机构：

[1] Food Standards Agcy, London WC2B 6NH, England

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2004年 / 42卷 / 04期

关键词：

amnesic shellfish poisoning; domoic acid; neurotoxin; pseudonitzchia multiseries;

D O I：

10.1016/j.fct.2003.11.010

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Amnesic shellfish poisoning (ASP) is caused by consumption of shellfish that have accumulated domoic acid, a neurotoxin produced by some strains of phytoplankton. The neurotoxic properties of domoic acid result in neuronal degeneration and necrosis in specific regions of the hippocampus. A serious outbreak of ASP occurred in Canada in 1987 and involved 150 reported cases, 19 hospitalisations and 4 deaths after consumption of contaminated mussels. Symptoms ranged from gastrointestinal disturbances, to neurotoxic effects such as hallucinations, memory loss and coma. Monitoring programmes are in place in numerous countries worldwide and closures of shellfish harvesting areas occur when domoic acid concentrations exceed regulatory limits. This paper reviews the chemistry, sources, metabolism and toxicology of domoic acid as well as human case reports of ASP and discusses a possible mechanism of toxicity. Crown Copyright (C) 2004 Published by Elsevier Ltd. All rights reserved.

引用

收藏

页码：545 / 557

页数：13

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